肠道相关分子微生态在婴儿胆汁淤积性肝病中的作用

The value of intestinal microflora associated molecules in infants patients with cholestatic liver disease

目的分析肠道微生态成分的变化与胆汁淤积性肝病发生、发展的关系。方法比较80例胆汁淤积性肝病患儿(研究组)和同期80例健康婴儿(对照组)粪便标本中细菌DNA A260值、双歧杆菌、乳酸菌、大肠杆菌数量及双歧杆菌/大肠杆菌(B/E值)。结果研究组患儿大肠杆菌数量与对照组比较有上升趋势(P<0.05);DNA A260值、双歧杆菌、乳酸菌数量及B/E值研究组均低于对照组(P<0.05)。研究组足月出生患儿大肠杆菌数量与非足月出生患儿比较有上升趋势(P<0.05);两组患儿DNA A260值、双歧杆菌、乳酸菌数量及B/E值比较,差异均无统计学意义(P均>0.05)。结论肠道微生态结构的变化与婴儿胆汁淤积性肝病的发生、发展有一定的关联,可为婴儿胆汁淤积性肝病的临床诊治和预防提供参考。

Objective To analyze the value of intestinal microflora associated molecules in infants patients with cholestatic liver disease.Methods Eighty cases of infants with cholestatic liver disease and 80 cases of healthy babies at the same period were selected for the research and the DNA A260 value,the quantity of Bifidobacterium,Lactobacillus,Escherichia coli and Bifidobacterium/E.coli （B/E value） were determined.Results The quantity of E.coli in research group was higher than that in control group （P ＜ 0.05）,while the DNA A260 value,Bifidobacterium,Lactobacillus,and the number of B/E value of the research group were lower than those of the control group （P ＜ 0.05）.The quantity of E.coli in research group born at term was higher than that of who born at non-full-term （P ＜ 0.05）,while the DNA A260 value,Bifidobacterium,Lactobacillus quantity and B/E value between the two groups had no statistically significant difference （P ＞ 0.05）.Conclusion There is certain associtation in the occurrence and development between cholestatic liver disease and gut microflora changes,which could provide reference for the treatment and prevention of cholestatic liver disease.