血吸虫蛋白激酶研究进展

Recent progress in protein kinases of Schistosoma

蛋白激酶在血吸虫生长发育、生殖发育及与宿主的相互作用等方面起着重要作用。蛋白激酶C(SmPKC1)、p38促分裂原激活蛋白激酶(p38 MAPK)分别抑制和促进血吸虫从毛蚴到母胞蚴的发育;Polo样激酶(SmPlks)、Ste样激酶(SmSLK)、细胞酪氨酸激酶(SmTK3,SmTK4,SmTK5和SmTK6)、金星激酶受体(SmVKR1和SmVKR2)、TGF-β受体(SmTGFβ-RⅠ和SmTGFβ-RⅡ)和cGMP依赖性蛋白激酶(SmcGK1)等分子可能与血吸虫的生殖发育有重要关系;而表面蛋白激酶(ecto-PK)、分泌蛋白激酶(exo-PK)、cAMP依赖蛋白激酶(PKA)和SmcGK1蛋白不仅与血吸虫的生长发育有关,还可能与血吸虫-宿主的相互作用有关。因此,血吸虫激酶可以作为阻断其生长与生殖发育的一个潜在的药物靶标。

Protein kinases were supposed to be crucial for the growth and reproductive development of schistosome,as well as the host parasite interactions.SmPKC1 and p38 MAPK were reported to inhibit and promote the development of schistosome from miracidium to mother sporocyst,respectively.SmPlks,SmSLK,SmTK3,SmTK4,SmTK5m,SmTK6,SmVKR1,SmVKR2,SmTGFβ-R Ⅰ,SmTGFβ-R Ⅱ,and SmcGK1 may play important functions in reproductive development of adults.As for ecto-PK,exo-PK,PKA and SmcGK1,these protein kinases were not only related to the growth of schistosome but also involved in the interplay between schistosome and its hosts.Therefore,schistosome kinases would be considered as potential drug targets for blocking the growth and reproductive development of parasite.