肝癌患者肝动脉化疗栓塞术后胆管损伤的研究进展

Recent advances on bile duct injury after transcatheter arteriai chemoembolization for hepatic malignancy

作为肝脏恶性肿瘤非手术治疗的常用方法，经导管肝动脉化疗栓塞术（TACE）的有效性及安全性已被大家认可。但在随后的运用过程中，也产生诸多并发症，如：上消化道出血、肝功能衰竭、肺栓塞、栓塞性胆囊炎等。胆管损伤作为其严重并发症之一亦有多篇报道。虽然对该并发症的发生机制、危险因素以及临床治疗目前仍存在较多问题，但查阅文献迄今未见这一并发症的相关文献综述。本文综合国内外文献，对目前存在的问题作一系统论述。

Transcatheter arterial chemoembolization （TACE） has been widely applied in palliative treatment of unresectable primary and metastatic liver cancer, and its efficiency and safety also have been widely acknowledged. However, there is a wide range of related complications, such as upper gastrointestinal hemorrhage, liver failure, pulmonary embolism, embolic cholecystitis and so on. As a serious complication of TACE, bile duct injury has been reported intermittently since the introduction of hepatic arterial embolization therapy. However, the exact pathogenesis, predisposing factors and clinical implications of the injuries remain to be clarified. As we find, by far there is no literature review about the bile duct injury after TACE for liver malignant tumors both at home and abroad. Thus the purpose of our study was to discuss such current issue of bile duct injury, and 26 articles have been included and analyzed.