婴儿原发性皮肤前体B淋巴母细胞性淋巴瘤1例并文献复习

Infant primary cutaneous pre B-cell lymphoblastic lymphoma:a case report and review of the literatures

报告1例婴儿原发性皮肤前体B淋巴母细胞性淋巴瘤。患儿男,52 d。因头皮肿物18 d,四肢及面部多发皮疹4 d就诊。头皮肿物组织病理学检查示:真皮浅层及皮下组织内见弥漫浸润的肿瘤细胞。瘤细胞体积小至中等大,胞质少,核类圆形,异形性明显,可见核仁,易见病理性核分裂象。肿瘤细胞CD10(+)、CD43(+)、B细胞淋巴瘤/白血病因子(BCL)-2(+)、末端脱氧核苷酸转移酶(TDT)(少量弱+)、细胞特异性活化蛋白(PAX)-5(强+)、Ki-67约80%(+);CD3(-)、CD20(-)、CD45RO(-)、CD34(-)、CD99(-)、CD79α(-)。诊断为原发性前体B淋巴母细胞性淋巴瘤。患儿家长放弃治疗,患儿2个月后死亡。

A case of infant primary cutaneous pre B-cell lymphoblastic lymphoma is reported. A 52-day-old boy presented with nodule on his scalp for 18 days and lesions on his face and limbs for 4 days. Histopathologic examination revealed diffuse tumor cell infiltration in the dermis and subcutaneous tissue. Tumor cells were atypical and varied in size with pathological mitosis. Tumor cells were positive for CDlO,CD43,BCL-2,TDT,Pax-5 and Ki-67 （80%）, and negative for CD3, CD20, CD45RO, CD34, CD99 and CD79α. The diagnosis was made of primary cutaneous pre B-cell lymphoblastic lymphoma. The parents gave up treatment and the patient died 2 months later.