抗菌药物对金双歧去除定植于肠道产ESBLs大肠埃希菌效果的影响研究

Impact of antimicrobial drugs against Jin Shuangqi to decolonize intestinal ESBLs producing Escherichia coli

目的研究抗菌药物对金双歧去除肠道产ESBLs大肠埃希菌定植效果的影响,为临床合理利用金双歧辅助治疗提供依据。方法选取崇州市人民医院2013年1月至2013年6月开展的"金双歧去除肠道产ESBLs大肠埃希菌定植的临床研究"科研项目中试验组患者102例,分成静脉使用抗菌药物组和未使用抗菌药物组,两组患者口服金双歧进行肠道内去定植。结果静脉使用抗菌药物组金双歧去除定植于肠道产ESBLs大肠埃希菌的去除率为30.30%;未使用抗菌药物组金双歧去除定植于肠道产ESBLs大肠埃希菌的去除率为41.67%。两组差异具有统计学意义(χ2=7.61,P<0.01)。结论抗菌药物对金双歧具有抑制和杀灭作用,使金双歧去除定植于肠道的产ESBLs大肠埃希菌能力减弱或消失。

Objective To study the impact of antibacterial drugs against the decolonization of intestinal ESBLs producing Escherichia coli by Jin Shuangqi, and provide basis for clinical rational use of the probiotic treatmeat. Methods 102 cases of patients in the experimental group of the clinical research Decolonization of intestinal ESBLs producing Escherichia coli by Jin Shuangqi conducted during January to June 2013 were selected and divided into intravenous antibiotics or non antibiotic group. Both groups were given orally Golden bifid （Jin shuangqi） for intestinal decolonization. Results The decolonization rate of Intravenous antibiotic group was 30.30% , while that of the non antibiotic group was 41.67%. The difference was statistically significant （X2 =7.61, P 〈0.01 ）. Conclusion Antibacterial drugs have inhibitory and killing effects on Jin Shuangqi, therefore can make the decolonizing effect of Jin Shuangqi on ESBLs producing Escherichia coli weakened or disappeared.