治疗2型糖尿病的生物药物研究进展

Research Progress of Biopharmaceuticals for Type 2 Diabetes Mellitus

目的对目前已上市的及正在研究中的治疗2型糖尿病的生物类药物作一综述。方法分类分析描述了目前已上市的经典的治疗2型糖尿病的生物类药物,并对目前正在研究中的新型药物进行了文献和报道的整理归纳。结果对治疗2型糖尿病的生物类药物及其最新研究进展进行了比较全面的总结。结论新的靶点和致病机理的发现使得生物类药物成为2型糖尿病新药开发中的重要类别,但目前已存在和正在开发的生物类药物仍存在诸多问题亟待进一步的改造与优化。

OBJECTIVE To summarize the research progress of biopharmaceuticals for type 2 diabetes mellitus. METHODS Both pharmaceuticals being studied and the classical ones were classified and described, with newly published articles introduced. RESULTS The research progress of biopharmaeeuticals for T2DM was comprehensively summarized. CONCLUSION The discovery of novel targets and pathogenic mechanism has made biopharmaceuticals a potent weapon for T2DM therapy, however, further optimization is needed and multiple problems still remain to be solved.