严重肺挫伤并发呼吸窘迫综合征机制和治疗的研究进展

Research progress about mechanism and therapy for critical pulmonary contusion complicated by acute respiratory distress syndrome

多发伤及胸部外伤常合并肺挫伤,严重肺挫伤并发急性呼吸窘迫综合征（ARDS）是患者死亡的主要原因之一.本文对肺挫伤并发ARDS的发生机制及治疗进行综述.研究表明,血流动力学改变、内皮损伤、炎症反应是肺挫伤发生ARDS的主要机制,对肺挫伤患者进行有效机械通气、液体复苏及清除炎症介质是早期防治ARDS的有效措施.

Acute respiratory distress syndrome （ARDS） which is commonly associated with polytrauma and chest trauma is one of the main causes of death in patients with pulmonary contusion.This article summarized the mechanism and therapies for critical pulmonary contusion envolving ARDS.Studies suggested that the change of hemodynamics,endothelial injury and inflammatory response are the the main mechanism of ARDS; effective mechanical ventilation,fluid resuscitation and removal of inflammatory mediators would be helpful to early prevention and treatment of ARDS.