奥拉西坦联合尼莫地平治疗血管性痴呆疗效观察

Efficacy of oxiracetam combined with nimodipine for treatment of vascular dementia

目的:探讨奥拉西坦联合尼莫地平治疗血管性痴呆(VD)的疗效。方法:将44例VD患者随机分为观察组和对照组各22例。在基础治疗的同时对照组加服尼莫地平,每次40 mg,每天3次;观察组采用尼莫地平(用法与剂量同对照组)联合奥拉西坦4.0 g加入0.9%氯化钠注射液250 ml静脉滴注,每天1次。2组均连续用药3周。比较2组总有效率和不良反应。结果:观察组总有效率为95.45%,高于对照组的81.82%(P<0.05)。观察组与对照组不良反应发生率分别为13.64%和9.09%,差异无统计学意义(P>0.05)。结论:奥拉西坦联合尼莫地平治疗VD效果显著,安全性较好,具有临床应用价值。

Objective： To investigate the curative effect of oxiracetam combined with nimodipine in the treatment of vascular dementia（ VD）. Methods： Forty-four VD patients were randomly divided into observation group and control group,with 22 cases in each. The control group were administered nimodipine 40 mg,3 times per day for 3 weeds in addition to the basic therapy; the observation group were given nimodipine（ the same dosage and usage with the control group） combined with oxiracetam 4. 0 g and 250 ml 0. 9% sodium chloride injection intravenous drip one time a day for 3 weeks. The total effective rate and adverse reaction of the two groups were observed and compared. Results： The total effective rate was 95. 45% in the observation group,which was higher than that 81. 82% in the control group（ P〈 0. 05）. The adverse reaction rates in the observation group and control group were 13. 64% and 9. 09%,respectively. The incidence of adverse reaction had no statistical difference between the two groups（ P〉 0. 05）. Conclusions：Oxiracetam combined with nimodipine is obviously effective and safe in the treatment of VD. It is of value for clinical application.