TAM 联合 PSA 诊断前列腺癌的临床研究

Clinical study of the combined use of TAM and PSA in diagnosis of prostate cancer

目的：探讨血清肿瘤相关物质（TAM）和血清前列腺特异抗原（PSA）联合检测鉴别诊断前列腺疾病及前列腺癌（PCa）的临床价值。方法 TAM 采用化学显色法定量测定，PSA 采用德国罗氏公司 Cobas e 601全自动电化学发光分析仪及配套试剂检测。结果慢性前列腺炎组、急性前列腺炎组、前列腺增生组和前列腺癌组 TAM敏感性分别为0.62%、1.94%、1.75%和94.94%，PSA 敏感性分别为40.12%、79.61%、47.81%和96.20%，PSA ﹢TAM 两项均阳性敏感性分别为0.62%、0.97%、0.88%和93.67%，TAM 特异性分别为21.33%、23.58%、25.27%和65.89%，PSA 特异性分别为47.42%、49.38%、53.62%和78.36%，PSA ﹢ TAM 两项均阳性特异性分别为20.17%、22.29%、24.56%和98.26%，差异有统计学意义（P 〈0.01）。结论 TAM 和 PSA 联合检测在敏感性和特异性上具有很好的互补作用，对鉴别诊断前列腺疾病及前列腺癌具有重要的临床价值。

Objective To investigate the clinical effects of the combined detection of serum tumor associated material（TAM）and serum prostatic specific antigen（PSA）on the differential diagnosis of prostate disease and prostate cancer. Methods The levels of TAM were detected by chemical colori-metry and the levels of PSA were detected by electrochemiluminescence immunoassay. Results The sensitivity of TAM in chronic prostate prostatitis group,acute prostate prostatitis group,BPH group and prostate cancer group was 0. 62% ,1. 94% ,1. 75% and 94. 94% ,respectively. The sensitivity of PSA in the four groups was 40. 12% ,79. 61% ,47. 81% and 96. 20% ,respectively. The sensitivity of the combined use of ATM and PSA was 0. 62% ,0. 97% ,0. 88% and 93. 67% ,respectively. The specifici-ty of TAM was 21. 33% 23. 58% ,25. 27% and 65. 89% ,respectively. The specificity of PSA was 47. 42% ,49. 38% ,53. 62% and 78. 36% ,respectively. The specificity of combined use of ATM and PSA was 20. 17% ,22. 29% ,24. 56% and 98. 26% ,respectively. There were significant differences （P 〈 0. 01）. Conclusions The combined detection of TAM and PSA has good complementary effect on the sensitivity and specificity,and has important clinical value in the differential diagnosis of prostate dis-ease and prostate cancer.