D-二聚体预测脑梗死的类型及严重的神经功能缺损

D-dimer Prediction of Subtypes and Neurological Deifcits in Patients with Cerebral Infarction

目的：探讨D-二聚体测定在不同TOAST亚型脑梗死中的临床意义。方法测定2010年～2012年102例脑梗死患者的D-二聚体，对脑梗死患者进行TOAST分型及NIHSS评分，观察D-二聚体测定与脑梗死分型及NIHSS评分的关系。结果与其它脑梗死亚型相比，心源性栓塞患者D-二聚体水平最高，神经功能缺损最严重（P＜0.01）。D-二聚体与NIHSS评分呈显著相关（r=0.800，P＜0.01），大动脉硬化组、小动脉闭塞组及其它原因组均无明显相关性（P＞0.05）。结论D-二聚体测定结合临床病史可以预测心源性栓塞类型的脑梗死及其严重的神经功能缺损。

Objective To explore the meaning of D-dimer in different subtypes of cerebral infarction. Meth-ods Detecting the levels of D-dimer, classifying the subtypes and assessing the NIHSS scores of the patients with cerebral infarction from 2010 to 2012 in our hospital. Investigating the association between the level of D-dimer and subtypes and NIHSS scores in patients. Results The highest level of D-dimer （P〈0.01） and NIHSS scores （P〈0.01） were found in patients with cardioembolism. D-dimer levels are signiifcantly correlated with the NIHSS scores （r=0.800, P〈0.01）. Conclusion The detection of D-dimer in combination with medical history may be a good tool for predicting cardioembolism and the severity of neurological deifcits.