老年冠心病患者血清瘦素、脂联素、血脂水平分析及其与冠状动脉病变的关系

Relationship of Serum Leptin, Adiponectin, Lipid and Coronary Artery Disease in Elderly Patients with Coronary Heart Disease

目的：探讨老年冠心病患者血清瘦素、脂联素及血脂水平与冠状动脉病变程度的关系。方法选择2011年1月～2012年6月收治的冠心病患者86例，其中稳定性心绞痛（SA）26例，不稳定性心绞痛（UA）28例，急性心肌梗死（AMI）32例，并选择同期门诊体检健康人30名作为对照组，应用酶联免疫吸附法（ELISA）检测各组血清瘦素、脂联素、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）水平。应用Gensini评分评价冠心病患者冠状动脉病变情况。结果①SA组、UA组、AMI组血清瘦素水平逐渐升高且明显高于对照组，组间差异有统计学意义（P＜0.05）；SA组、UA组、AMI组血清脂联素水平逐渐降低且明显低于对照组，组间差异有统计学意义（P＜0.05）。②AMI组、UA组、SA组TG、TC、LDL明显高于对照组（P＜0.05）；AMI组、UA组HDL水平明显低于对照组（P＜0.05）。③冠心病患者血清脂联素水平随Gensini评分升高而逐渐降低，瘦素、TG、TC、LDL水平随Gensini评分升高而逐渐升高，组间差异有统计学意义（P＜0.05）。结论老年冠心病患者血清瘦素、TG、TC、LDL水平异常升高，血清脂联素水平异常降低，两者变化与冠状动脉病变程度密切相关。

Objective To investigate the relationship of serum leptin, adiponectin, lipid and coronary artery disease in elderly patients with coronary heart disease. Methods 86 patients with coronary heart disease were re-cruited which were treated in January 2011-June 2012, including 26 stable angina （SA） patients, unstable angina （UA） 28 cases, acute myocardial infarction （AMI） 32 cases, and 30 health people were selected from outpatient as the control group, enzyme-linked immunosorbent assay （ELISA） were used to detect the levels of serum leptin, adiponectin, triglyceride （TG）, total cholesterol （TC）, low-density lipoprotein （LDL） and high density lipoprotein （HDL）. Coronary artery lesions were applied by Gensini score in all patients. Results 1.The levels of serum leptin were increased gradually and signiifcantly increased among SA, UA group and AMI group. The statistics were sig-niifcant （P〈0.05）;while adiponectin were signiifcantly decreased in SA, UA, AMI group than in control group （P〈0.05）. 2.TG, TC and LDL were signiifcantly increased （P〈0.05） in AMI, UA, SA group than in control group;HDL were decrease only in AMI and UA group than the control group （P〈0.05）. 3. Serum adiponectin were in-creased while Gensini score decreased, leptin, TG, TC, LDL were consistent with Gensini score. Also differences was signiifcant between two groups （P〈0.05）. Conclusion Serum leptin, TG, TC and LDL were increased while adiponectin were decreased in elderly patients with coronary heart disease, all were closely related to the severity of coronary lesions.