我院2010-2012年住院患者头孢菌素类抗菌药物应用分析

Analysis of the Utilization of Cephalosporins in the Inpatient Department of Our Hospital during the Period of 2010-2012

目的:了解住院患者头孢菌素类抗菌药物使用现状及发展趋势,为其进一步规范管理提供参考。方法:依据医院药品信息库提供的数据,对我院2010-2012年住院患者头孢菌素类抗菌药物的种类、用药金额、用药频度(DDDs)等进行统计分析。结果:3年来,我院住院患者头孢菌素类抗菌药物的品种数、销售金额逐年下降,其中2012年出现大幅度下降;DDDs呈逐年下降趋势。从构成结构上看,第二代头孢菌素在2012年取代第三代头孢菌素,位居各类头孢菌素销售金额之首。3年来DDDs排序一直在前10位的药物有注射用头孢硫脒、注射用头孢哌酮/舒巴坦、注射用头孢孟多、注射用头孢替安4个品种。结论:我院头孢菌素类抗菌药物以第二、三代为主,第一代品种受限,但属于第一代头孢菌素的注射用头孢硫脒DDDs排序一直靠前。注射用头孢硫脒存在过度使用现象,这将会导致细菌耐药的增加,应引起有关部门的重视,进一步加强管理和监测。

OBJECTIVE： To evaluate the status quo and the tendency of cephalosporins for inpatients in our hospital, and to provide reference for further standard management. METHODS： According to hospital database, the utilization of cephalosporins for inpatient in our hospital during 2010--2012 was analyzed statistically in respects of categories, consumption sum, DDDs, etc. RESULTS： During 3 years, both the categories and the consumption sum of cephalosporins for inpatients Were decreasing year by year, and in 2012 this trend was the most obvious. DDDs was also decreasing year by year. The consumption sum of third-genera- tion cephalosporins had gradually dominated the first places but was surpassed by that of the second-generation cephalosporins in 2012. Top 10 cephalosporins in the list of DDDs during 3 years were Cephathiamidine for injection, Cefoperazone/sulbactam for in- jection, Cefamandole nafate for injection and Cefotiam for injection. CONCLUSIONS： The consumption sum of the third-and the second-generation cephalosporins is dominating the first places. The use of the first-generation cephalosporins is restricted in categories, but Cephathiamidine for injection which belongs to the first-generation cephalosporins is always in the front part in the list of DDDs. Cephathiamidine for injection is overused somehow and thus leading to increase bacterial drug resistance. This situation should be taken seriously by the departments to strengthen management and monitoring.