我院694例药品不良反应报告分析

Analysis of 694 Cases of ADR Reports in Our Hospital

目的:了解我院药品不良反应(ADR)发生的特点,促进临床合理用药。方法:对我院2008-2013年收集的694例ADR报告按患者的年龄、性别、给药途径、用药情况及ADR临床表现等进行回顾性分析。结果:694例ADR报告中,给药途径以静脉给药为主,占73.34%;药品种类中抗感染药引发ADR例数最多(占57.35%),其次为中药制剂(占19.31%);ADR损害器官或系统以皮肤及其附件为主(占45.10%),其次为神经系统和消化系统(分别占25.36%和19.02%)。结论:临床应提高ADR监测报告质量,加强抗感染药的合理使用,减少ADR的发生,保障公众用药安全。

OBJECTIVE： To investigate the characteristics of ADR in our hospital, and to promote rational drug use. METH- ODS： A total of 694 ADR reports in our hospital during 2008- 2013 were analyzed statistically in respects of age and gender, route of administration, drug categories and clinical manifestations, etc. RESULTS： Among 694 cases, intravenous administration took the lead among the routes of administration （73.34%）; 57.35% were induced by anti-infective drugs, showing the biggest pro- portion, followed by TCM preparations （19.31%）; ADR dominantly manifested as lesions of skin and its appendants （45.10%）, followed by injury of nervous system and digestive system （25.36% and 19.02 % ）. CONCLUSIONS： Great importance must be attached to the quality of ADR monitoring and use of anti-infective drugs should be strengthened in order to reduce the occurrence of ADR and guarantee the safety of drug use in the public.