我院286例药品不良反应报告分析

Analysis of 286 Cases of ADR Reports in Our Hospital

目的:了解我院药品不良反应(ADR)发生的情况,为加强药品安全监测、指导临床合理用药提供参考。方法:收集我院2013年度上报国家ADR监测网并通过中心审核的286例ADR报告,根据患者性别、年龄、药品种类、药品剂型、给药途径、ADR累及器官或系统等进行回顾性统计、分析。结果:以50岁以上的中老年患者ADR发生率最高(占51.05%);静脉滴注给药是引起严重ADR的主要途径(占77.85%);引起ADR的药品以抗肿瘤及辅助药为主(占66.08%);严重的ADR表现以红细胞异常最为常见(占34.51%);引起严重红细胞异常的前10位药品均为抗肿瘤药,报告最多的是顺铂、多西他赛、环磷酰胺等。结论:临床应加强临床医务工作者对ADR的认知度,尤其是应重视对抗肿瘤药ADR的监测,以减少或避免ADR的发生,促进合理用药。

OBJECTIVE： To investigate the occurrence of ADR in our hospital, and to provide reference for drug safety moni- toring and rational use of drugs in the clinic. METHODS： According to ADR monitoring network in 2013, 286 ADR reported by our hospital were checked and analyzed statistically in respects of age, gender, drug types, dosage form, route of administration, organs or systems involved in ADR, etc. RESULTS： The incidence of ADR in patients aged more than 50 years old was highest, accounting for 51.05% ; intravenous infusion was the main reason of the serious ADR（77.85% ） ; ADR was mainly caused by an- ti-tumor drugs（66.08% ） ; abnormal RBC was the most common manifestation of serious ADR（34.51% ） ; top 10 drugs causing the severe abnormal RBC were anti-tumor drugs, and the most frequently reported drugs were cisplatin, docetaxel, cyclophosphamide, etc. CONCLUSIONS： The awareness of clinical staff to ADR should be strengthened, especially on antineoplastic drugs-inducing ADRs monitoring, in order to decrease or avoid the occurrence of ADR and the medical disputes and improve rational drug use in the clinic.