靶向肿瘤新生血管整合素αvβ3受体显像研究现状及进展

Progress on tumor angiogenesis imaging targeting integrin αvβ3 receptor

恶性肿瘤的生长和转移依赖于肿瘤血管新生，研究发现整合素αvβ3高表达于肿瘤新生血管内皮细胞和部分肿瘤细胞表面，可通过介导细胞粘附来调控肿瘤血管新生，而整合素αvβ3在正常血管和组织表面不表达或呈低水平表达，据此可将其用作肿瘤新生血管显像和治疗的新靶点。近年来国内外关于整合素αvβ3靶向药物的设计、放射性核素的选择以及此类药物的最新研究内容有了较大进展，笔者将对如何更好地设计整合素αvβ3靶向药物、选择合适的放射性核素以及此类药物的研究方向进行综述。

Malignant tumors′growth and metastasis depend on tumor angiogenesis. Recent studies had found that the integrin αvβ3 had a high expression on the surface of tumor angiogenesis endothelial cells and parts of the tumor cells, it can regulate tumor angiogenesis by cell adhesion, but it does not ex-press on the surface of normal blood vessels or the normal organizations, or only had a low level expression. Thus it can be used as a new target for the tumor angiogenesis imaging and treatment. Recent years, there is a great progress on the design of the integrinαvβ3 targeting agents, the selection of radionuclides, and the latest research on the agents at home and abroad. This article will made a review on how to better design the integrinαvβ3 agents, choose the appropriate radionuclides, and the research direction of these agents.