社交焦虑障碍的家系对照研究

Case-control family study of social anxiety disorder

目的探讨社交焦虑障碍的家庭聚集性及遗传因素在社交焦虑障碍的发生中的作用。方法采取以人群为基础的病例对照家系研究,调查76例社交焦虑障碍患者及76例正常对照者的一级亲属社交焦虑障碍患病及家族史等情况,比较两组亲属社交焦虑障碍的患病比例,检验社交焦虑障碍家庭聚集性;采用Falconer法估计其遗传度;采用Li-Mantel-Gart法计算分离比。结果社交焦虑障碍先证者一级亲属患病比例(8.94%)高于对照者一级亲属患病比例(3.76%),差异有统计学意义(χ2=3.91,P<0.05),证明存在家族聚集性;社交焦虑障碍先证者一级亲属遗传度为37.8%;根据社交焦虑障碍在家系中的分布情况进行分离分析得到分离比为0.1466(P<0.25),表明社交焦虑障碍可能属于多因子遗传病。结论遗传因素在社交焦虑障碍发病中起着重要作用,社交焦虑障碍家族史增加社交焦虑障碍发病风险。

Objective To explore households clustering in Social Anxiety Disorder（SAD）and the function of hereditary factors in the occurrence of social anxiety disorder （SAD）.Methods Based on a population-based case-control family study,in order to test the households clustering of SAD,an investigation was performed in 76 patients with SAD and 76 health controls as well as the situations of their first-degree relatives and their family medical history,comparing positive rate of the two groups.Simultaneously,Falconer Law and Li-Mantel-Gart Law were adopted respectively to estimate the heredity degree and calculate segregation ratio.Results The incidence rates of SAD in the patients＇ first-degree relatives was 8.94％,which was higher than that of the controls.Statistically,therewas a significant difference （x2 =3.91,P ＜ 0.05） to test the existence of households clustering.And,the heredity degree of the patients＇ first-degree relatives was 37.8％ and the segregation ratio was 0.1466.Conclusion Hereditary factor plays a very important role in the occurrence of SAD,and the family medical history may increase the risk of the SAD.