WWOX与p73蛋白在乳腺癌组织中的表达及相关性研究

Expression and correlation of WWOX and p73 protein in breast carcinoma

目的探讨WWOX与p73蛋白在乳腺癌组织中的表达及其相关性。方法采用免疫组织化学方法检测60例浸润性乳腺癌、20例乳腺纤维腺瘤及20例乳腺癌旁组织中WWOX和p73的表达情况。结果 WWOX在浸润性乳腺癌组织中的表达(13.3%)明显低于乳腺纤维腺瘤组织(35.0%)(P<0.05),乳腺纤维腺瘤组织中的表达明显低于乳腺癌旁组织(75.0%)(P<0.05)。WWOX的表达与有无淋巴结转移、分化程度、TNM分期、术后复发及ER受体密切相关(P<0.05)。p73在乳腺癌组织中的表达(80.0%)明显高于乳腺纤维腺瘤组织(55.0%)(P<0.05),乳腺纤维腺瘤组织中的表达明显高于乳腺癌旁组织(15.0%)(P<0.05)。p73的表达与有无淋巴结转移、术后复发、ER受体密切相关(P<0.05)。WWOX与p73在浸润性乳腺癌组织中的表达呈负相关(r=-0.489,P<0.05)。结论 WWOX和p73参与调控乳腺癌的发生、发展,联合检测WWOX和p73对预测乳腺癌的发生、发展及评估乳腺癌患者的预后有重要意义。

Objective To study the expression and correlation of WWOX and p73 in breast carcinoma.Methods Immunochemical method was performed to detect the expression of WWOX and p73 in 60 cases of breast carcinoma,20 cases of benign breast tissues and 20 cases of cancer surrounding tissues.Results Expression of WWOX in breast cancinoma tissue（13.3%）was significantly lower than that in benign breast tissues （35.0%） （P 〈0.05）.The latter was significantly lower than that in cancer surrounding tissues （75.0%） （P 〈 0.05）.The expression of p73 was closely related to lymph node metastasis,cytodifferentiation,TNM stages,postoperative recurrence,estrogen receptor and HER-2 receptor （P 〈 0.05）.Expression of p73 in breast cancinoma tissue （80.0%）was_significantly higher than that in benign breast tissues（55.0%） （P 〈0.05）.The latter was significantly higher than that in cancer surrounding tissues （15.0%） （P 〈 0.05）.p73 was closely related to lymph node metastasis,postoperative recurrence,estrogen receptor,HER-2 receptor（P 〈 0.05）.The expression of WWOX was negative correlated with p73 （P 〈 0.05）.Conclusion WWOX and p73 might play an important role in occurence and development of breast carcinorma.The combined detection of WWOX and p73 might be a more appropriate method to identify the formation and development of breast carcinoma and to predict the prognosis of breast carcinoma.