摘要
目的探讨DKK1在不同雌孕激素受体状态的子宫内膜癌组织中的表达及意义。方法采用免疫组化检测DKK1在子宫内膜癌及正常子宫内膜组织中的表达及定位;比较DKK1表达水平在不同雌孕激素受体状态子宫内膜癌组织及正常子宫内膜组织的差异,并探讨其与子宫内膜癌临床病理特征之间的关系。结果免疫组化结果显示DKK1蛋白主要表达于子宫内膜癌腺上皮上,基质中少量表达。DKK1在雌孕激素受体阴性子宫内膜癌组织中的表达水平高于雌或孕激素受体阳性组和正常子宫内膜组,差异具有统计学意义(P<0.05)。DKK1蛋白表达水平与雌孕激素受体状态、有无淋巴结转移密切相关(P<0.05),而与患者年龄、病理分级、分期无关(P>0.05)。结论 DKK1在雌孕激素受体阴性子宫内膜癌组织中高表达。
Objective To investigate the expression of DKK1 in hormone-resistant endometrial cancer and to explore its significance.Methods Immunohistochemistry was performed to measure the DKK1 expression in the endometrium at different hormone receptor statuses.The correlation between DKK1 expression and clinicopathological characteristics of EC was analyzed.Results Immunohistochemistry showed DKK1 protein was mainly found in the glandular epithelium and but less in the stroma.The DKK1 expression in the estrogen and progesterone receptor negative EC was markedly higher than that in the estrogen or progesterone receptor positive EC and the normal endometrium（P 〈 0.05）.DKK1 protein expression was closely related to the hormone receptor status and lymph node metastasis （P 〈 0.05）,but unrelated to the age,pathological grade and stage of EC （P 〉 0.05）.Conclusion The DKK1 is preferentially expressed in hormone-resistant endometrial cancer.
出处
《中华临床医师杂志（电子版）》
CAS
2013年第10期79-81,共3页
Chinese Journal of Clinicians(Electronic Edition)
基金
广东省科技厅基金资助课题(2011B031800383)
