湘西香醋体内抗氧化及其淡化黄褐斑作用的研究

The Anti-oxidation and Chloasma-removing Activity of Xiang-Xi Vinegar:A Vivo Study

目的:研究湘西香醋对肌肉注射黄体酮小鼠产生的黄褐斑的淡化作用,探讨其可能的机制。方法:采用肌肉注射黄体酮构造黄褐斑小鼠模型,灌胃不同剂量的湘西香醋30 d,测定小鼠肝脏和皮肤组织的MDA、NO含量、SOD活力,制作小鼠皮肤石蜡切片,观察皮肤黑色素分布情况。结果:湘西香醋具有明显的抗氧化效果,与模型组相比,香醋组小鼠的肝脏和皮肤组织MDA含量明显降低,SOD活力明显升高,NO含量明显降低,绝大多数组的差异有统计学意义(P<0.05),特别是湘西香醋降低小鼠肝脏和皮肤组织MDA、皮肤组织NO含量的效果非常显著(P<0.01)。饲喂香醋后,小鼠皮肤黄褐斑数量明显少于模型组,黄褐斑颜色深度也明显比模型组浅。结论:湘西香醋在小鼠体内有较强的抗氧化活性,并具有淡化黄褐斑的功效。

Objective： To investigate the effect of Xiang-Xi vinegar on the chloasma and the possible mechanism.Methods： To build chloasma mice model via intramuscular injections of progesterone,and then fed different doses of Xiang-Xi vinegar for thirty days,determine the MDA content,NO content,SOD activity of liver and skin of mouse,and observe the distribution of melanoma in skin.Results： Xiang-Xi vinegar has a remarkable antioxidant effects,MDA content and NO content in liver and skin decreased,and SOD activity increased significantly（p 0.05）.The number of mouse skin chloasma was less than progesterone treated group,chloasma color was also notably shallow than the progesterone treated group.Conclusion： Xiang-Xi vinegar has a great ability of anti-oxidation and can remove chloasma caused by intramuscular injection of progesterone in mouse.