长链非编码RNA在中枢神经系统中的研究进展
被引量:2
摘要
长链非编码RNA(10ngnob—codingRNA,lncRNA)是一类长度为200nt至100kb、缺乏显著开放阅读框(oar)的非编码RNA(ncRNA)。据估计,人类基因组大约含有7000~23000条lncRNA。研究证实,lncRNA与生物进化、胚胎发育、物质代谢以及肿瘤发生等都有着密切的联系。在中枢神经系统的研究中,lncRNA参与了神经元分化、脑发育、突触可塑性以及神经退行性疾病及肿瘤的发生、发展。因此,对中枢神经系统中lncRNA功能和作用机制的深入研究将丰富我们对脑发育、功能和疾病的认识,同时也可为某些治疗药物的设计与研发提供新思路。
出处
《中华临床医师杂志(电子版)》
CAS
2013年第2期152-154,共3页
Chinese Journal of Clinicians(Electronic Edition)
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