颈动脉内膜中层厚度与血管内皮功能的相关性

Correlation between intima-media thickness and high sensitivity C-reactive protein, homocysteine,fibrinogen and vascular endothelial function

目的：观察颈动脉内膜中层厚度（IMT）与血管内皮功能包括反应性充血后内径变化率（FMD）、含服硝酸甘油后血管内径变化率（NMD）及相关因子的相关性。方法纳入2012年7月～2013年7月广东省阳江市人民医院体检人群150例，根据颈动脉内膜中层厚度，将患者分为三组，每组50例。A组：IMT＜1.0 mm；B组：1.0 mm≤IMT＜1.5 mm；C组：IMT≥1.5 mm。对入选者行空腹血糖（FPG）、血脂、肌酐、超敏C反应蛋白（hs-CRP）、同型半胱氨酸（Hcy）、纤维蛋白原（Fib）、FMD、NMD检测，统计分析三组患者各项指标的差异。结果三组患者在血糖、胆固醇（TC）、低密度脂蛋白（LDL-C）、肌酐方面比较无统计学差异（P＞0.05）。B、C两组患者hs-CRP、Hcy、Fib均值水平高于A组，FMD、NMD均值水平均低于A组，差异有统计学意义（P＜0.05）。C组患者hs-CRP、Hcy均值水平高于B组，差异有统计学意义（P＜0.05）。hs-CRP（r=0.459，P＜0.05）、Hcy（r=0.432，P＜0.05）和Fib（r=0.485，P＜0.05）均与IMT呈正相关。结论 IMT与内皮功能密切相关，与内皮功能有关的hs-CRP、Hcy、Fib均与IMT正相关。

Objective To observe the correlation between intima-media thickness （IMT） and vascular endothelial function （FMD and NMD） and its relative factors.Methods The patients （n=150） were chosen from Jul. 2012 to Jul. 2013 and then divided, according to IMT degree, into three groups （eachn=50）, including group A （IMT0.05）. The average levels of hs-CRP, Hcy and Fib were higher, and FMD and NMD were lower in group B and group C than those in group A （P〈0.05）. The average levels of hs-CRP and Hcy were higher in group C than those in group B. The levels of hs-CRP, Hcy and Fib were all correlated to IMT （hs-CRP：r=0.459; Hcy：r=0.432; Fib：r=0.485, allP〈0.05）.Conclusion IMT is closely correlated to vascular endothelial function and levels of hs-CRP, Hcy and Fib.