老年脑梗死患者红细胞分布宽度与动脉硬化相关性研究

Association between red blood cell distribution width and pulse wave velocity in elderly inpatients with cerebral infarction

目的探讨老年脑梗死患者红细胞分布宽度(RDW)与脉搏波传导速度(PWV)之间的相关性。方法对162例老年脑梗死住院患者进行横断面研究,按RDW四分位数将患者分为:最低四分位数组(A组)33例,低四分位数组(B组)39例,高四分位数组(C组)50例,最高四分位数组(D组)40例。收集临床一般资料及脑血管病危险因素,测定空腹血糖、血脂、糖化血红蛋白、肌酐、白细胞、血红蛋白、平均红细胞体积(MCV)、高敏C反应蛋白等,测量PWV。结果从A组到D组,PWV逐渐增高,分别为1903.00±361.23、1961.62±445.98、2021.84±427.11、2175.73±492.99,D组较A组和B组差异有统计学意义(P<0.05,P<0.01);相关分析显示,RDW与PWV(r=0.189,P<0.05)、MCV(r=0.170,P<0.05)呈正相关,与血红蛋白呈负相关(r=-0.214,<0.01);Logistic回归分析显示,RDW为PWV的危险因素(OR=3.549,95%CI:61.394～216.107;P<0.01)。结论老年脑梗死患者的RDW与PWV相关,RDW增高患者动脉硬化程度增加。

Objective To investigate the association between red blood cell distribution width （RDW）and pulse wave velocity（PWV）in elderly inpatients with cerebral infarction.Methods A total of 162 elderly inpatients with cerebral infarction were included in this cross-sectional study.Patients were categorized according to quartiles of RDW into four groups：the lowest RDW quartile group（A group,n =33）,low RDW quartile group（B group,n =39） high RDW quartile group （C group,n =50）,the highest RDW quartile group （D Group,n =40）,whose clinical date and risk factors of cardiovascular diseases （CVD） were collected,fasting glucose,serum lipid,hemoglobin A1c,createnine,white blood cell,hemoglobin,mean corpuscula volume as well as high-sensitivity C-reactive protein were measured.PWV was measured.Results There were graded increases in the level of PWV （1903.00 ± 361.23,1961.62 ± 445.98,2021.84 ± 427.11,2175.73 ± 492.99）,PWV were graded increases in group D than group A and group B （P ＜ 0.05,P ＜ 0.01）.There was a positive correlation between RDW and PWV （r =0.189,P ＜ 0.05）,MCV（r =0.170,P ＜ 0.05） and a negative correlation between RDW and Hb （r =-0.214,P ＜ 0.01）.After adjusting for other traditional arteriosclerosis risk factors RDW was risk factor for PWV （OR =3.549,95％ CI：61.394-216.107,P ＜ 0.01）.Conclusions Among elderly inpatients with cerebral infarction,RDW is related to PWV.Patients with increased RDW arterial stiffness increases.