前列腺癌肺或胸膜转移十例临床研究

Clinical study of lung and pleural metastases from prostate cancer(report of 10 cases)

目的探讨前列腺癌肺或胸膜转移临床特点。方法回顾分析2010年1月至2012年11月105例经活检证实为前列腺癌的患者,其中10例患者通过超声引导下肺或胸膜穿刺确诊为前列腺癌肺或胸膜转移。通过临床调查、实验室检查及病理结果并复习文献分析前列腺癌肺或胸膜转移的临床特点。结果前列腺癌肺或胸膜转移主要见于老年男性,以呼吸系统症状为首发症状6例,以泌尿系统症状为首发症状4例,10例均通过超声引导下肺或胸膜穿刺确诊,确诊前列腺癌肺转移9例,胸膜转移1例,同时伴有骨转移7例,病理学Gleason评分5分1例、6分2例、7分7例。结论对于以呼吸系统症状为首发症状、前列腺特异性抗原升高、直肠指诊异常的男性患者应加强前列腺癌筛查,以免延误诊治。

Objective To explore the clinical features of pulmonary and pleural metastases from prostate cancer.Methods 105 cases with biopsy-proven prostate cancer between Jan.2010 and Nov.2012 were reviewed.10 cases were diagnosed pulmonary or pleural metastases from prostate cancer through ultrasound-guided lung or pleural puncture.The clinical features of pulmonary and pleural metastases from prostate cancer were analyzed through clinical investigation,laboratory tests,pathological findings and review of the literature.Results Pulmonary and pleural metastases from prostate cancer were mainly seen in older men,4 cases started with respiratory symptoms,6 cases started with urological symptoms,10 cases diagnosed through ultrasound-guided lung or pleural puncture,9 cases were diagnosed with pulmonary metastases,one case was diagnosed with pleural metastases,7 cases accompanied by bone metastases,one case＇ Gleason grade was five,2 cases of six,7 cases of seven.Conclusions For male patients with respiratory symptoms starting,PSA increased or abnormal digital rectal examination,screening for prostate cancer should be strengthened so as to avoid delay in treatment.