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树突状细胞在慢性阻塞性肺疾病中的作用

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摘要 慢性阻塞性肺疾病（chronic obstructive pulmonary disease,COPD）是一组以不完全可逆的气流受限为特征的疾病.气道持续进行的非特异性慢性炎症,伴有急性加重,小气道重塑及终末气道损害是气流不可逆受限的病理机制[1].迄今对于COPD的发病机制还不明确,被认为是肺部对于有害气体及有害颗粒的异常炎症反应有关.COPD的气道炎症以中性粒细胞、巨噬细胞、CD8＋T细胞浸润为主[2],提示固有免疫及适应性免疫均参与了COPD的发病.树突状细胞（DC）作为目前已知的最强的抗原提呈细胞,是联系固有免疫及特异性免疫的枢纽[1],参与并调控免疫反应在COPD的发病中起着一定的作用.本文就近年来对有关文章从香烟对DC的影响及DC与COPD的关系等方面作一综述.
作者 张力予 宋卫东
机构地区 北京大学深圳医院呼吸科 安徽医科大学
出处 《中华临床医师杂志（电子版）》 CAS 2013年第6期171-172,共2页 Chinese Journal of Clinicians(Electronic Edition)
基金 深圳市重点科研课题(200801002)
关键词 慢性阻塞性肺疾病 树突状细胞 PULMONARY COPD 发病机制 抗原提呈细胞 气流受限 终末气道
分类号 R563.9 [医药卫生—呼吸系统]
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参考文献11

  • 1张临友,杨英男,杨宝峰.树突状细胞亚群及其功能[J].国外医学（免疫学分册）,2004,27(5):260-263. 被引量：3
  • 2Bratke K,Klug M,et al.Function-associated surface molecules on airway dendritic cells in cigarette smokers[].Am J Respir Cell Mol Biol.2008
  • 3Robbins CS,Dawe DE,Goncharova SI,et al.Cigarette smoke decreases pulmonary dendritic cells and impacts antiviral immune responsiveness[].Am J Respir Cell Mol Biol.2004
  • 4Demedts IK,Bracke KR,Van Pottelberge G, et al.Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease[].American Journal of Respiratory and Critical Care Medicine.2007
  • 5Freeman CM,Martinez FJ,Han MK.et al.Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease[].American Journal of Respiratory and Critical Care Medicine.2009
  • 6Tsoumakidou M,Demedts IK,Brusselle GG Et al.Dendritic Cells in Chronic Obstructive Pulmonary Disease: New Players in an Old Game[].American Journal of Respiratory and Critical Care Medicine.2008
  • 7Liu YJ.Dendritic cells subsets and lingeages and their functions in innate and adaptive immuneity[].Cell.2001
  • 8Galgani M,Fabozzi I,Perna F,et al.Imbalance of circulating den-dritic cell subsets in chronic obstructive pulmonary disease[].CliImmunol.2010
  • 9Hodge G,Nairn J,Holmes M, et aL.Increased intracellular T helper 1 proinflammatory cytokine production in peripheral blood, bronchoalveolar lavage and intraepithelial T cells of COPD subjects[].Clinical and Experimental Immunology.2007
  • 10D‘hulst Al,Vermaelen KY,Brusselle GG, et al.Time course of cigarette smoke-induced pulmonary inflammation in mice[].European Respiratory Journal.2005

二级参考文献19

  • 1Mazariegos GV,Zahorchak AF, Reyes J, et al. Dendritic cell subset ratio in peripheral blood correlates with successful withdrawal of immunosuppression in liver transplant patients [ J ]. Am J Transplant, 2003,3 (6):689-696.
  • 2Jonuleit H, Schmitt E, Schuler G, et al. Induction of interleukin 10-pro-ducing, nonproliferating CD4( + ) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendiitic cells[J]. J Exp Med,2000,192(9): 1213-1222.
  • 3Jong C, Vieira L, Kalinski P, et al. Microbial Compounds Selectively Induce Th1 Cell-Promoting or Th2 Cell-Promoting Dendritic Cells In Vitro with Diverse Th Cell-Polarizing Signals[J] .J Immunology,2002,168(4):1704-1709.
  • 4Gomez J, Borras FE, Singh R, et al. Differential up-regulation of HLA-DM,invariant chain, and CD83 on myeloid and plasmacytoid dendritic cells from peripheral blood[J] .Tissue Antigens,2004,63(2): 149-157.
  • 5Pulendran B, Banchereau J, Burkeholder, et al. Flt3-1igand and granulocyte colonystimulating factor mobilize distinct human dendritic cell subsets in vivo[J]. J Immunol, 2000,165(1): 566-572.
  • 6Kuwana M, Kaburaki J, Wright T, et al. Induction of antigen-specific human CD4+ T cell anergy by peripheral blood DC2 precursors[J]. EurJ Immunol,2001,31 (9) :2547-2557.
  • 7Durbin JE, Fernandez-Sesma A, Lee CK. Type I IFN modulater innate and specific antiviral immunity[J].J Immunol,2000,164(8) :4220-4228.
  • 8Waldmann H, Cobbold S. Regulating the immune response to transplants:a role for CD4+ regulatory cells? [J]. Immunity,2001,14(4) :399-406.
  • 9Gilliet M,Liu YJ.Generation of human CD8 T-regulatory cells by CD40ligand-activated plasmacytoid dendritic cells [ J ]. J Exp Med, 2002, 195(6) :695-704.
  • 10Dhodapkar MV,Steinman RM, Krasovsky J,et al. Antigen-specific inhibition of effector T-cell function in humans after injection of immature dendritic cells[J].J ExP Med,2001,193(2) :233-238.

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中华临床医师杂志（电子版）
2013年 第6期

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