乳腺良、恶性疾病与血清雌、孕激素及雌孕激素受体的关系

Correlation of the serum hormone estradiol and progesterone levels and estrogen and progesterone receptors with the disease associated with breast

目的探讨血清雌二醇、孕激素及雌、孕激素受体在乳腺各组疾病中的变化及其关系。方法用化学发光免疫法测定282例乳腺疾病及100例健康女性术前血清雌二醇、孕酮,术后用免疫组化法检测130例乳腺疾病及30例正常乳腺组织雌孕激素受体,分析血清雌孕激素及受体与乳腺疾病的关系。结果血雌、孕激素含量在乳腺各组疾病中和对照组比较无显著差异性,年龄<40岁组中血雌二醇含量在乳腺增生症患者中较高,年龄≥40岁组雌二醇、孕酮激素含量在乳腺癌、乳腺纤维腺瘤患者中均较高,差异均有统计学意义。血清雌孕激素含量高及雌孕激素受体阳性率高在乳腺癌患者中较明显,乳腺各组血清雌二醇、孕酮水平较高组和同时其测定雌孕激素受体均阳性及强阳性的患者标本观察,发现乳腺癌雌二醇水平及ER、PR阳性及强阳性例数明显高于其他组。结论雌孕激素受体阳性在乳腺癌患者中较显著,乳腺各组血清雌二醇、孕酮水平较高组和同时其测定雌孕激素受体均阳性及强阳性的患者发现乳腺癌明显高于其他组,在临床上指导早期发现及治疗乳腺癌有重要参考意义。

Objective To investigate the changes and relationship of serum E 2, progestogen, estrogen receptor（ ER） and progesterone receptor （ PR） in different groups of breast diseases .Methods 282 patients with breast diseases and 100 healthy women were detected serum estrogen and progestogen by the chemiluminescence immunoassay before operation ,130 patients with breast diseases and 30 normal breast tissues were detected ER and PR by the immunohistochemistry post-operation,analyse the relationship between estrogen ,progestogen,ER,PR and breast diseases .Results There were no significant deviation between disease group and control group .Group of age less than 40-year-old ER were significant higher than others , group of age more than 40-year-old shown that the estrogen and progestogen in adenofibroma and breast cancer group were higher than others .The ER and PR were significant high in each group , especially in breast cancer group .As group factors ER and PR promote the cell proliferation in normal breast tissue and breast cancer .The overexpression of ER and PR stimulate breast preneoplastic change and lead to breast cancer finally .Conclusion The serum ER and PR significant masculine in breast cancer patients .There are important reference meaning in the treatment guidance of breast cancer ,can rivalry ER and PR or neutralized overdose estrogen and progestogen .