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肿瘤浸润未成熟树突状细胞诱导血管生成的研究进展 被引量：3

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摘要 我国肾癌发病率逐年上升，其中最常见的病理类型是肾透明细胞癌。肾癌早期临床症状不明显，约30％患者在就诊时已经存在转移病灶，许多患者在手术后出现转移。对于转移性肾癌目前常用的放疗、化疔及细胞免疫治疗等方法疗效均有限。近年来出现的抑制肿瘤血管生成（tumor angiogenesis）的多靶点酪氨酸激酶抑制剂是最有效、特异性最高的治疗方式，但超过50％患者口服药物后仍有肿瘤进展。
作者 张亮 张斌 麦海星 陈立军
机构地区 安徽医科大学解放军第 军事医学科学院附属医院泌尿外科 军事医学科学院细胞与基因治疗中心
出处 《中华临床医师杂志（电子版）》 CAS 2013年第13期160-161,共2页 Chinese Journal of Clinicians(Electronic Edition)
基金 吴阶平医学基金(32067521203)
关键词 抑制肿瘤血管生成 肿瘤浸润 细胞诱导 树突状 未成熟 酪氨酸激酶抑制剂 肾透明细胞癌 转移性肾癌
分类号 R730.3 [医药卫生—肿瘤]
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参考文献26

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同被引文献67

  • 1于丹丹,魏于全.恶性肿瘤的生物化疗研究及进展[J].中华临床医师杂志（电子版）,2011,5(16):4828-4830. 被引量：7
  • 2柳永蕾,宋现让.乏氧诱导因子结构、表达及调控[J].中国生物化学与分子生物学报,2006,22(1):1-8. 被引量：9
  • 3Jakel CE,Schmidt-Wolf IG.An update on new adoptivei - mmunotherapy strategies for solid tumors with cytokine-induceci killer cells.Expert Opin Biol Ther,2014,14(7):905-916.
  • 4Hontscha C,Borck Y,Zhou H,et al.Clinical trials on CIK cells:first report of the international registry on CIK cells(IRCC).J Cancer Res Clin Oncol,2011,137(2):305-310.
  • 5Su X,Zhang L,Jin L,et al,Immunotherapy with cytokine-inducedkiller cells in metastatic renal cell carcinoma.Cancer Biother Radiopharai,2010,25(4):465-470.
  • 6Olioso P,Giancola R,DiRiti M,et al.Immunotherapy with cytokine induced killer cells in solid and hematopoietic tumours:a pilot clinical trial.Hematol Oncol,2009,27(3):130-139.
  • 7Ma Y,Zhang Z,Tang L,et al.Cytokine-induced killer cells in the treatment of patients with solid carcinomas:a systematic review and pooled analysis.Cytotherapy,2012,14(4):483-493.
  • 8Tao L,Huang G,Shi S,et al.Bevacizumab improvesthe antitumor efficacy of adoptive cytokine-induced killercells therapy in nonsmall cell lung cancer models.Med Oncol,2014,31(1):777.
  • 9Liu L,Zhang W,Qi X,et al.Randomized study of autologous cytokine-induced killer cell immunotherapy in metastatic renal carcinoma.Clinical Cancer Research,2012,18(6):1751-1759.
  • 10Ma Y,Aymeric L,Locher C,et al.The dendritic cell-tumor crosstalk in cancer.Current opinion immunology,2011,23(1):146-152.

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中华临床医师杂志（电子版）
2013年 第13期

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