摘要
目的:观察并探讨宫颈癌术前行TP与PF两种新辅助化疗方案的临床效果,优选新辅助化疗方案。方法:将2008年1月-2010年12月间入选的91例Ib-Ⅱa宫颈癌患者随机分为A(n=46)、B(n=45)两组,A组患者子宫切除术前予TP新辅助化疗方案,B组予PF方案,各2个周期,对比化疗结束后两组临床疗效、化疗期间药物毒性反应及术后2年内宫颈癌复发率。结果:①A、B两组总体有效率分别为89.1%、82.2%,差异不具有统计学意义(P>0.05),但前者化疗后瘤体直径明显小于B组(P<0.05);②两组药物毒性反应构成不具有统计学差异(P>0.05),但A组胃肠道反应与肝脏毒性发生率明显低于B组(P<0.05);③A、B两组组术后2年内宫颈癌复发率分别为2.2%、11.9%,复发率无统计学差异(P>0.05)。结论:宫颈癌术前TP新辅助化疗方案较之BIP方案具有比较优势,更具备临床推广价值。
Objective:The paper is to investigate and explore the clinical effect of cervical cancer underwent TP or PF two kinds of neoadjuvant chemotherapy(NACT),and to prefer the better neoadjuvant chemotherapy scheme.Methods:91 cases from Jan.2008 to Dec.2010 were randomized divided into A(n=46) B(n=45) group,group A was given TP(DDP +TAX) NACT scheme before radical hysterectomy,group B was given PF(DDP+5-Fu) scheme,and each with 2 treatment cycles,comparison on clinical effect after NACT,drug toxicity and recurrence rate within 2 years after hysterectomy were conducted between 2 groups.Results:①0verall efficiency of A,B group were 89.1%,82.2% respectively,the difference was not statistically significant(P〉0.05),but the diameter of tumor of group A after chemotherapy was significantly less than that of group B(P〈0.05);②Constitution of drug toxicity of 2 groups was not statistically different(P〉0.05),but the incidence rate of gastrointestinal reaction liver toxicity of group A was significantly lower than that of group B(P〈0.05);③Recurrence rates of A B group within 2 years after surgery were 2.2%,11.9% respectively,also with no significant difference(P〉0.05).Conclusion:Neoadjuvant chemotherapy of TP scheme compared with BIP scheme has comparative advantage,and have more clinical value of popularization.
出处
《现代生物医学进展》
CAS
2014年第12期2267-2270,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(30872464)
关键词
宫颈癌
新辅助化疗
顺铂
紫杉醇
疗效
Cervical cancer
Neoadjuvant chemotherapy
Cisplatin
Paclitaxel
Clinical efficacy