妊娠期肝内胆汁淤积导致新生儿肺损伤的高危因素及干预对策

Risk Factors and Interventions of Neonatal Lung Injury Caused by Intrahepatic Cholestasis of Pregnancy

目的:探讨妊娠期肝内胆汁淤积症综合症所致新生儿肺损伤的危险因素,并采取相应的措施以提高临床治疗水平。方法:选取2010年1月-2013年1月我院收治的70例妊娠肝内胆汁淤积症综合症患者作为观察组,另选取同期接受体检的65例正常晚期妊娠妇女为对照组。分析新生儿肺损伤的相关因素。结果:妊娠肝内胆汁淤积症综合症所致新生儿肺损伤高危险因素有高雌激素水平、机体免疫失衡、高微量元素硒、高总胆汁酸、高甘胆酸(p均<0.05)。结论:妊娠肝内胆汁淤积症综合症所致新生儿肺损伤的高危因素较多,临床上要积极采取措施,避免产后母婴并发症的发生。

Objective：To investigate the risk factors of syndrome of intrahepatic cholestasis of pregnancy induced lung injury in neonatal,and take corresponding measures in order to improve the level of clinical treatment.Methods：70 patients with neonatal lung injury induced by intrahepatic cholestasis of pregnancy from January 2010 to January 2013 were selected as the observation group,and another 65 pregnant women who were accepted the inspection at the same time were chosen to be the control group.Then the related factors of neonatal lung injury were analyzed by regression.Results：The high risk factors of neonatal lung injury induced by intrahepatic cholestasis of pregnancy were high estrogen levels,immune imbalances,high-selenium,high total bile acid,high cholyglycine（P〈0.05）.Conclusion：Many high risk factors are related to intrahepatic cholestasis of pregnancy induced neonatal lung injury syndrome.It is suggested that the active measures should be taken to avoid the postpartum complications of maternal and infants.