儿童哮喘与肺炎支原体感染关系的探讨

Study on Relationship Between the Infection of Mycoplasma pneumoniae and Bronchial Asthma in Children

目的:探讨儿童哮喘发作与肺炎支原体(MP)感染之间的关系,并分析合并MP感染的患儿的临床表现。方法:将79例2-14岁急性哮喘发作的患儿依据病史分做两组:第一次哮喘发作的35人(始发哮喘组),已经有哮喘病史的44人(复发哮喘组)。采用被动冷凝集法检测两组患儿肺炎支原体抗体(MP-IgM)。结果:始发哮喘组和复发哮喘组分别有16例(45.7%)和10例(22.7%)患儿MP-IgM阳性(P<0.05)。始发哮喘组与复发哮喘组MP-IgM阳性的患儿发热和肺部啰音发生率明显高于MP-IgM阴性的患儿(P<0.05),血清IgE水平也明显高于MP-IgM阴性的患儿(P<0.05)。结论:MP感染与儿童哮喘发作关系密切,合并MP感染的哮喘患儿发热或肺部啰音发生率明显高于未合并MP感染的哮喘患儿。

Objective：to test the connection between acute Mycoplasma pneumoniae（MP） infection and the exacerbation of asthma.The clinical characteristics of asthmatic children with MP infection were reviewed.Methods：We examined the cases of 79 asthma exacerbation patients aged from two to fourteen years old.They were divided into two groups according to their asthma history.35 had only had their first asthma attack（initial group） and 44 cases had evidence of a history of asthma（known group）.MP infection was defined by positive results in serologic testing with Passive condensation set method.Results：MP infection was found in 16 children（45.7%） in initial group and 10 children（22.7%） in known group（P〈0.05）.In two groups,compared with children without MP infection,the incidence of fever and rales among children with MP infection and the level of serum IgE were significantly higher（P〈0.05）.Conclusions：MP may play a role in asthmatic exacerbation among children.Moreover,among children with MP infection,the number was significantly increased of children having fever as the chief complaint and rales in auscultations compared with those without MP infection.