实验性牙周炎合并咬合创伤模型的研究进展

Research on Experimental Animal Model of Periodontitis Combined Occlusal Trauma

不正常的咬合接触关系或者过大的咬合力,造成咀嚼系统各部位的病理性损害或者适应性变化称为咬合创伤,而牙周炎是一种慢性炎症性疾病,是由牙菌斑生物膜引起的牙周组织的感染性疾病,导致牙周支持组织的破坏-牙周袋形成和炎症、进行性的附着丧失和牙槽骨吸收。近年来有学者对咬合创伤作为一类独立疾病进行研究,也有学者将咬合创伤作为牙周炎的一个重要的局部促进因素进行研究。牙周炎和咬合创伤的关系至今不是很明确,关于咬合创伤和牙周炎的相互关系,虽然早在20世纪初已开始研究,却直到70年代才有严格对照的动物实验研究。大鼠牙周炎合并咬合创伤的模型在牙周炎和咬合创伤关系的相关研究中起着十分重要的作用。本文从牙周炎和咬合创伤复合模型的建立方面,综述了各种建模方法的研究进展,以期为牙周炎合并咬合创伤的深入研究提供参考。

Abnormal occlusal contact relations or the bite force too big resulting in a Pathological damage of masticatory system or adaptive changes,which is called occlusal trauma.While periodontitis is a chronic inflammatory disease,it is a infectious diseases which is caused by dental plaque biofilm in periodontal tissue.It always cause periodontal tissue destruction,such as periodontal pocket formation and inflammation or the resorption of alveolar bone.In recent years,some scholars research occlusal trauma as a kind of independent disease,and some scholarsas a matter of periodontitis local catalyst.The relationship of periodontitis and occlusal trauma is not very clear so far.Although the relationship of the occlusal trauma and periodontitis has been started to research at the beginning of the 20th century,until the 70s there have been strictly controlled animal experiment research.Animal model of periodontitis combined occlusal trauma in rats plays a very important role in the relationship between periodontitis and occlusal trauma related research.In order to provide reference for further study of periodontitis combined occlusal trauma,this paper reviews the research progress of modeling of the composite model and several other aspects.