真菌性角膜病变的两种药物治疗疗效对比分析

Contrast analysis of two kinds of drug therapy in fungal corneal disease

目的通过真菌性角膜溃疡应用那他霉素和氟康唑治疗的对照研究,研究那他霉素与氟康唑在真菌性角膜溃疡的治疗作用。方法对24例24眼确诊真菌性角膜溃疡患者随机分为A、B两组,每组12例,分别用那他霉素眼液及氟康唑眼液进行治疗。结果 A组(那他霉素组)12眼治愈9眼,有效10眼,无效2眼,有效率83%;B组(氟康唑组)12眼,治愈4眼,有2效8眼,无效4眼,有效率66%;两组有效率比较,差异无统计学意义(χ=1.587,P>0.05);那他霉素组治愈率75%明显2高于氟康唑组33%,差异有统计学意义(χ=5.048,P<0.05);结论那他霉素对真菌性角膜溃疡具有较好的治疗作用,优于氟康唑。

Objective To study the clinical effective of natamycin and fluconazole in the treatment of fungal corneal ulcer .Methods 24 eases （24 eyes）with fungal corneal ulcer were randomly divided into A, B groups, natamycin eye drops was used in group A and fluconazole eye drops in group B. Results In group A, 9 eyes were cured, effective in 10 eyes, ineffective in 2 eyes, the efficiency was 83% and 4 eyes was cured, effective in 8 eyes ,ineffective in 4 eyes, the effective rate was 66% in group B. The were no significantly changes between two groups（ χ2= 1.587, P 〉 0.05 ）.The cure rate of group A was 75%, group B was 33%, the difference was statistically signifieant（χ2= 5.048, P 〈 0.05）.Conclusion Compared with flueonazole eye drops, natamycin eye drops has better therapeutic effect on fungal corneal ulcer, worth being vigorously recommended.