糖尿病合并肺结核患者诱导耐药性危险因素的回归分析

Regression analysis of risk factors of induced drug resistance in patients of Type 2 Diabetes combined with tuberculosis

目的:研究2型糖尿病(Type 2 Diabetes,T2DM)合并肺结核(Tuberculosis,TB)患者诱导耐药性危险因素的回归分析。方法:从2012年3月到2013年3月,于我院共计有124例患者被确诊为肺结核,将其作为研究对象。根据患者是否合并有2型糖尿病,将其分成观察组(49例)及对照组(75例)。对全部患者进行耐药性实验,分别经单因素分析及Logistic回归性分析寻找诱导耐药性的危险因素。结果:观察组在治疗过程中断、有吸烟习惯、依从性差、病程≥1年、HbAlc值≥6.5%等方面所占比例显著高于对照组,差异均有统计学意义(均P<0.05)。由多因素分析可知,治疗过程中断、有吸烟习惯、依从性差、病程≥1年、HbAlc值≥6.5%等均为糖尿病合并肺结核患者的危险因素。结论:T2DM合并TB患者诱导耐药性的危险因素较多,临床应重点关注,并采取相应措施,从而为临床治疗提供更为有利的条件。

Objective： To study risk factors of induced drug resistance in patients of Type 2 Diabetes combined with tuberculosis through regression analysis. Methods： 124 patients who were diagnosed with TB from March 2012 to March 2013 in our hospital were selected as a research object. Patient with type 2 diabetes were divided into 2 groups, those who were with tuberculosis were in observation group（49 cases） while the rest were in control group（75 cases）. All patients were subjected to the drug resistance experiments. Single factor analysis and logistic regression analysis were used for the test of risk factors of induced drug resistance respectively. Results： In observation group, the occurrences of treatment interruption, smoking habits, poor compliance, duration ≥ 1-year, HbAlc values ≥6.5% were significantly higher,and the differences were statistically significant（P〉 0.05）. According to the multivariate analysis, the treatment interruption, smoking habits, poor compliance, duration ≥ 1-year, HbAlc values ≥ 6.5%, were risk factors in diabetic patients with pulmonary tuberculosis＇ s risk factors. Conclusion： There are quite a number of risk factors for inducing drug resistance in patients with T2DM combined TB. More attention and measures should be taken so that more favorable conditions for clinical treatment can be provided.