VEGF和Survivin在肾癌中的表达及其相关性研究

VEGF and Survivin Expression and Their Relationship in Renal Cell Carcinoma

目的:探讨肾癌组织中血管内皮生长因子VEGF与凋亡抑制蛋白Survivin表达的相关性及其之间的关系,研究Survivin和VEGF在肾癌发生发展中的作用机制。方法:应用免疫组织化学方法检测70例肾癌组织和70例癌旁正常肾脏组织中VEGF和Survivin的表达,并将检测结果与临床病理特征进行综合分析。结果:VEGF和Survivin在肾癌中表达均高于癌旁正常肾脏组织;Survivin和VEGF在肾癌中的阳性表达率分别为75.71%(53/70)和72.86%(51/70),在癌旁肾脏组织中的表达率分别为0%(0/70)、17.14%(12/70),差异均有显著性意义(P<0.05);VEGF和Survivin的表达与患者的性别、年龄、肿瘤大小、病理分级均无相关性;VEGF和Survivin表达呈正相关性。结论:VEGF和Survivin在肾癌组织中表达率较高,为肾癌的分子靶向治疗提供了新的靶点。Survivin和VEGF在RCC中的表达关系密切,测定RCC中Survivin、VEGF蛋白的表达,有助于临床判断病人预后。

Objective： To study the expression of vascular endothelial growth factor（VEGF） and Survivin in renal cell carcinoma（RCC）and its relationships, research Survivin and VEGF in renal cell carcinoma development mechanism. Methods： The expression of VEGF and Survivin in70 renal cell carcinoma specimens and 70 normal kidney tissue specimens were detected by immunohistochemistZ ry, and the result was analyzed in relation to the patients＇ clinicopathologic characteristics. Results： The expression of VEGF and Survivin in renal cell carcinoma were higher than those in the normal kidney tissue specimens. Of the 70 RCC specimens, 53（75.71%） were positive forSurvivin expression, and 51（72.86%） were positive for VEGF expression. Survivin expression was not detected in normal kidney tissue, and 12（17.14%） of these tissues were positive for VEGF, showing significant difference in Survivin and VEGF expressions between RCC specimens and normal kidney tissue;VEGF and Survivin expression were not correlated to the patient＇s gender, ager tumor size, pathological grade（P〉0.05）. Correlation analysis indiccated a close correlation between the expressions of VEGF and Survivin in renal cell carcinoma specimens. Conclusion： VEGF and Survivin are over-expressed in renal cell carcinoma specimens, and may theoretically serve as the targets of molecular targeted drugs. Detection of the expressions of Survivin and VEGF in RCC tissues may provide assistance for prognostic evaluation of the patients.