非酒精性脂肪性肝病与代谢综合征组分的相关性研究进展

Advances of Correlation between Nonalcoholic Fatty Liver Disease and the Components of Metabolic Syndrome

非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)在全世界人群中发病率逐年上升,成为新的全球公共健康问题,已越来越引起临床关注。其发病以胰岛素抵抗为基础,与肥胖、血脂紊乱、原发性高血压、2型糖尿病等代谢综合征各组分密切相关。NAFLD可进展至肝硬化、肝衰竭甚至肝癌,伴有代谢综合征一种或多种组分可能加速疾病的进展。NAFLD初期是一种可逆性过程,充分了解影响其发生、发展的相关代谢危险因素并及时纠正,可能导致疾病的逆转或延缓其进程。本文就NAFLD与代谢综合征各组分的相关调查研究进行综述。

Nonalcoholic fatty liver disease is increasing in population all over the world. As a new global public health problem, it arouses more and more clinical concernsand not clear its pathogenesis up to now. The onset of nonalcoholic fatty liver disease is on the basis of insulin resistance while related to components of metabolic syndrome including obesity, dyslipidemia, essential hypertension and diabetes. The disease may progress to liver cirrosis, liver failure or liver cancer, one or more components of metabolic syndrome associated with NAFLD may accelerate the progress of the disease, Early NAFLD is a reversible process, fully understanding of the impact of metabolic risk factors on its occurrence and development and promptly correcting it, may result in disease reversal or slowing down its progression. which is a hot topic of research recently. This paper briefly reviewed theits progerss of the research between NAFLD and components of metabolic syndrome.