胰岛素抵抗的2型糖尿病人群的血脂分析

Lipid analysis of type 2 diabetes mellitus patient population who with insulin resistance

目的：探讨胰岛素抵抗的2型糖尿病（T2DM）人群血脂与对照组、2型糖尿病非胰岛素抵抗组的。方法：分别测定159例2型糖尿病患者及132例健康人群（CON组）空腹血糖、空腹胰岛素、三酰甘油、高密度脂蛋白-胆固醇、低密度脂蛋白-胆固醇和胆固醇，并计算胰岛素抵抗指数（IR）。结果：（1）CON组与胰岛素抵抗的T2DM组比较，两间FBG、FIN、IRI、TG、HDL、LDL差异有统计学意义（P〈0.05）；（2） CON组与非胰岛素抵抗的T2DM组比较，两组间FBG、CHOL、HDL差异有统计学意义（P〈0.05）；（3）胰岛素抵抗的T2DM组与非胰岛素抵抗的T2DM组比较，两组间FBG 、FIN、 IRI、TG、CHOL差异有统计学意义（P〈0.05）。（4） IR与FBG、FIN、TG、HDL有显著相关性。结论：2型糖尿病患者的脂代谢与胰岛素抵抗密切相关，推测有胰岛素抵抗的2型糖尿病患者容易发生血脂紊乱。

Objective： to investigate the correlation between insulin resistance in type II diabetes mellitus（IR） of the lipid and the control group and the non-insulin-resistance in Type 2 diabetes mellitus.Methods：The levels of fasting blood glucose, fasting insulin, HOMA-IR, TG, HDL-CH, LDL-CH, and CHOL were measure in 159 type 2 diabetes and the control group by 132 common health examination persons.Results：（1） There were statistical differences of FBG ,FIN, IRI, TG, HDL and LDL between the insulin resistance in T2DM patients and the control group（P〈0.05）.（2） There were statistical differences of FBG,CHOL and HDL between the non-insulin-resistance in T2DM patients and the control group（P〈0.05）.（3） There were statistical differences of FBG ,FIN, IRI, TG and CHOL between the insulin resistance in T2DM and the non-insulin-resistance in T2DM patients.（4） It had significant correlativity between IR with FBG, FIN, TG and HDL.Conclusions：A positive correlation between IR and Lipid metabolism in T2DM. It is conjectured that there is easy for the patients with T2DM of non-insulin-resistance to have Lipid metabolism.