摘要
目的：探讨IL-22在类风湿关节炎（rheumatoid arthritis，RA）不同时期患者中的临床意义。方法：用酶联免疫吸附法检测35例活动组RA患者、35例缓解组 RA 患者及30例健康人血清 IL-22的水平，并分析它与活动度和实验室指标的关系。结果：RA活动组和 RA 缓解组IL-22水平均明显高于对照组，差异均有统计学意义（p〈0.05），而 RA 活动组与 RA 缓解组相比，差异亦有统计学意义（p〈0.05）。RA 患者血清 IL-22与 DAS28评分、血沉、C 反应蛋白、类风湿因子均呈正相关关系（p〈0.05）。结论：IL-22可能参与了 RA 的发病过程，并可将其血清水平作为RA活动参考指标。
Objective：To investigate clinical significance of changes of the serum IL-22 of different periods in patients with RA.Methods：The Patients were divided into different groups according to the RA disease activity score （DAS28）,35 patients with active RA and 35 patients with inactive RA .Thirty healthy volunteers were recruited as the normal control.Concentrations of serum IL-22 was measured by Enzyme linked immunosorbent assay （ELISA）.The relationship between IL-22 and DAS28 and laboratory data was analyzed at the same time.Results： Compared with the normal control, the levels of serum IL-22 in patients with RA were significantly increased（p〈0.05）, and there showed the satatistic differences between patients with active RA and inactive RA（p〈0.05）. The levels of serum IL-22 was positively correlated with 28 joint Disease Activity Score,ESR,CRP and RF（p〈0.05）.Conclusions：The results suggest that IL-22 may play a role in the pathogenesis of RA and it’s level can be an indicator of disease activity.
出处
《医学检验与临床》
2014年第2期15-17,共3页
Medical Laboratory Science and Clinics
基金
佛山市卫生局课题（2014097）
