丹参酮ⅡA对心血管系统保护作用及机制的研究进展

Protective effects and mechanism of tanshinone Ⅱ A on cardiovascular system

心血管疾病是全球发病率和致死率最高的疾病,而丹参酮ⅡA对心血管系统具有突出的保护作用。本文综述了丹参酮ⅡA对血管内皮、平滑肌、心肌以及心肌成纤维细胞的保护作用及可能机制,从抑制细胞增殖、改善氧化应激损伤、改善迁移黏附功能等具体机制方面进行阐释,以期为丹参酮ⅡA的合理应用提供依据。

Cardiovascular disease （CVD） contributes to the world＇s highest morbidity and mortality rates while tanshinone Ⅱ A plays an outstanding effect on protecting cardiovascular system.This paper reviews the effects of tanshinone Ⅱ A on protecting vascular endothelial cell,smooth muscle cell,cardiomyocyte and cardiac fibroblast cell and the possible mechanism of inhibiting cell proliferation,antagonizing oxidative stress,improving adhesion function and migration and other aspects to provide evidence on clinical use of tanshinone Ⅱ A.