TAP、FOXJ1基因多态性与自身免疫性疾病相关性的研究进展

Research progress of the relationship between TAP,FOXJ1 gene polymorphism and autoimmune disease

自身免疫性疾病(AD)是指机体对自身抗原发生免疫反应导致自身组织损害所引起的疾病。AD发病机制尚未明确,近年来国内外学者越来越多地将目光投在遗传背景上,欲从分子水平上探讨其病因,特别是TAP、FOXJ1基因多态性与自身免疫性疾病的研究备受关注。

Autoimmune diseases（AD）is the body＇s own antigens to the immune response leading to its tissue damage caused by the disease.Its pathogenesis is not yet entirely clear.In recent years,more and more research had been done at the gene level in the domestic and overseas,to explore its pathogenesis from molecular level.Especially the research about TAP,FOXJ1 gene polymorphism and autoimmune disease has been concerned.