放射治疗在乳腺癌患者综合治疗中的作用

Effect of radiotherapy in treatment of comprehensive treatment of breast cancer

目的 探讨放射治疗在乳腺癌患者综合治疗中的作用.方法 选择2010年12月～2011年12月在本院治疗的70例Ⅰ、Ⅱ期乳腺癌患者,随机分为观察组与对照组,每组各35例,对照组采用保乳手术＋术后辅助化疗,观察组在对照组的基础上加用放射治疗,比较两组患者的治疗效果及不良反应发生情况.结果 观察组的生存率为97.14％ （34/35）、远处转移率为2.85％ （1/35）,对照组生存率为97.14％（34/35）、远处转移率2.85％ （1/35）,组间差异无统计学意义（P＞0.05）;观察组的局部复发率为2.85％ （1/35）,对照组为11.42％ （4/35）,组间差异有统计学意义（P＜0.05）;观察组的放疗不良反应共13例,对照组16例,组间差异无统计学意义（P＞0.05）;观察组患者的术后生存质量与外观美容效果均明显优于对照组,组间差异有统计学意义（P＜0.05）.结论 放射治疗能降低乳腺癌患者的术后复发率,提高美容效果与患者的生存质量,值得推广应用.

Objective To investigate the effects of radiotherapy in comprehensive treatment of breast cancer patients. Methods 70 cases of Ⅰ , Ⅱ stage breast cancer patients treated in our hospital during December 2010 to December 2011 were selected,they were randomly divided into observation group and control group,35 cases in each group,the control group treated with breast-conserving surgery plus adjuvant chemotherapy,the observation group treated with ra- diotherapy based on the control group,the therapeutic effects and adverse reactions were compared. Results The sur- vival rate in observation group was 97.14%（34/35）,distant metastasis rate was 2.85% （1/35）,those of the control group was 97.14% （34/35）, and 2.85% （1/35）,no significant difference between the groups （P〉0.05）.Local recurrence rate of observation group was 2.85% （1/35）,that of the control group was 11.42% （4/35）,the difference was statistically signifi- cant （P〈0.05）.Observation group had 13 cases of adverse reactions,the control group had 16 cases of adverse reactions, there was no significant difference between the groups （P〉0.05）.Postoperative quality of life and appearance cosmetic results of the observation group were significantly better than those of the control group （P〈0.05）. Conclusion Radiation therapy can reduce the recurrence rate of breast cancer patients and improve cosmetic results and quality of life of pa- tients,it is worthly of popularization and application.