幽门螺杆菌阴性消化性溃疡与出血的相关性分析

Correlation analysis between Helicobacter pylori(Hp) negativepe ptic ulcer and hemorrhage

目的 分析总结幽门螺杆菌（Hp）阴性消化性溃疡疾病与出血的相关性,以指导出血症状的临床预防工作.方法 以本院2011年9月～2013年9月收治的190例消化性溃疡患者为研究对象,对其临床资料进行回顾性分析.按病原学检查有无Hp感染,将76例Hp阳性及114例Hp阴性的患者分为Hp阳性组和Hp阴性组,并收集各组影像学和组织学资料,对数据进行统计,分析其与出血症状的相关性.结果 Hp阳性组中24例伴发出血,占31.6％,52例未合并出血,占68.4％; Hp阴性组中69例伴发出血,占60.5％,45例未合并出血,占39.5％.Hp阴性组并发出血率显著高于Hp阳性组,差异有统计学意义（P＜0.05）.初检阴性患者1个月后复查Hp感染情况,无病例转为阳性.结论 Hp阴性是消化性溃疡并发出血的高危因素,可提高合并出血的发生率,临床工作中应对该因素提高警惕.

Objective To analyze and summarize the correlation between Helicobacter pylori （Hp） peptic ulcer and hemorrhage,in order to guide the clinical prevention of hemorrhage. Methods 190 cases of peptic ulcer patients were selected as the research objects in our hospital from September 2011 to September 2013.According to the etiological examination of Hp infection,the patients were divided into Hp positive group in 76 cases and Hp negative group in 114 cases,iconography and histology datas were collected and retrospectively analyzed for analyzing the correlation between that and hemorrhage. Results There were 24 cases with hemorrhage in Hp positive group,which accounted for 31.6%, and 69 cases with hemorrhage in the Hp negative group,accounting for 60.5%,45 cases with no bleeding,accounted for 39.5%. Compared with the the Hp positive group,the hemoorhage rate of Hp negative group was significantly higher （P〈0.05）.After the initial inspection one month,the re-examination of Hp infection showed that no cases turned positive. Conclusion Negative Hp is the risk factor for peptic ulcer combined with hemorrhage,can improve the incidence of hemorrhage,which should be alerted in the clinical.