生鲜乳中林可霉素、四环素、土霉素和多西环素在不同储存条件下的稳定性研究

Stability of Lincomycin, Tetracycline, Terramycin and Doxycycline in Raw Milk under Different Storage Conditions

本研究旨在通过检测不同储存条件下林可霉素(LIN)、四环素(TET)、土霉素(TER)和多西环素(DOX)的残留量分析其在生鲜乳中的储存稳定性,包括储存温度和时间,复温温度、冻融次数和添加防腐剂等。试验结果显示,生鲜乳中LIN、TET、TER和DOX在相同的储存温度条件下,储存时间越长,稳定性越低;在相同的储存时间条件下,储存温度越高,稳定性越低;复温温度对这四种抗生素稳定性影响不显著;冻融次数越多,稳定性越低;LIN在添加防腐剂条件下稳定性较好;TET在添加重铬酸钾和甲醛条件下稳定性较差;TER和DOX在添加硫氰酸钠、叠氮钠、重铬酸钾、溴硝丙二醇和甲醛条件下稳定性均较差。本研究探讨了牛奶安全监测工作中LIN、TET、TER和DOX的最佳储存条件,为确保监测结果的准确性提供理论依据。

This study aimed to evaluate the stability of lincomycin（LIN）, tetracycline（TET）, terramycin（TER） and doxycycline（DOX） in raw milk under different storage conditions, such as storage temperature and time, thawing temperature, freeze-thaw cycle times, and the addition of preservatives. Results showed that their degradation rate increased with the increasing storage temperature and time and freeze-thaw cycle times. The influence of thawing temperature to storage stability was insignificant. LIN was quite stable with containing preservatives. TET degraded with containing potassium dichromate and methanal, TER and DOX were unstable when added sodium thiocyanate, sodium azide, potassium dichromate, bronopol and methanal in raw milk. This work attempts to find out the optimal storage condition of LIN, TET, TER and DOX in raw milk and ensure the accuracy of the results in milk safety monitoring.