心房纤颤对缺血性心肌病患者血浆NT-proBNP水平的影响

Effect of Atrial Fibrillation on Plasma NT-proBNP Level in Patients with Heart Failure Induced by Ischemic Cardiomyopathy and Related Factors Analysis

目的探讨心房纤颤对缺血性心肌病患者血浆氨基末端脑钠肽前体(NT-proBNP)水平的影响。方法选择缺血性心肌病患者120例,按是否存在心房纤颤分为心房纤颤组(n=56)和非心房纤颤组(n=64)。分别检测两组血浆NT-proBNP水平,并作心脏超声检测左心房内径(LAD)、左心室内径(LVD)及左心室射血分数(LVEF)。结果缺血性心肌病心房纤颤组血浆NT-proBNP水平、LAD和LVD高于缺血性心肌病非心房纤颤组,而LVEF值低于缺血性心肌病非心房纤颤组,差异有统计学意义(P<0.05);缺血性心肌病心房纤颤组患者血浆NT-proBNP水平与患者年龄、心房纤颤持续时间、左心房内径、左心室内径呈正相关,与射血分数呈负相关。结论缺血性心肌病合并心房纤颤患者较之缺血性心肌病非心房纤颤患者NT-proBNP水平明显升高,且NT-proBNP水平与年龄、心房纤颤持续时间、左心房内径、左心室内径有关。

Objective To discuss the effect of atrial fibrillation on plasma NT - proBNP level in patients with heart failure induced by ischemic cardiomyopathy and related factors analysis. Methods Totally 120 cases of patients with ischemic cardiomyopathy were ran- domly divided into atrial fibrillation group （ n = 56） and no atrial fibrillation group（ n = 64） according to the presence of atrial fibrillation. The plasma NT - proBNP level, left atrium diameter（LAD） , left ventricular diameter（LVD） and left ventricular ejection fraction （LVEF） were detected in two groups. Results The plasma NT -proBNP levels, LAD and LVD in the patients with atrial fibrillation group were higher than that in no atrial fibrillation group, and LVEF value was lower than that in no atrial fibrillation group, the difference was statis- tically significant （ P 〈 0.05 ）. The plasma NT - proBNP levels were positively correlated with the age, the duration of atrial fibrillation,left atrial diameter and left ventricular diameter, but negative correlation with the ejection fraction. Conclusion The NT - proBNP level in patients with ischemic cardiomyopathy and atrial fibrillation increased significantly, and the NT - proBNP correlated with the age, the du- ration of atrial fibrillation, left atrial diameter and left ventricular diameter.