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肾癌常见亚型的生物学特性和CT特征 被引量:9

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摘要 肾细胞癌(renal cell carcinoma,RCC)简称肾癌,起源于肾小管上皮细胞,是肾实质肿瘤中最常见的一种恶性肿瘤,占成人所有肾脏恶性肿瘤的90%、所有恶性肿瘤的3%[1].近30年来肾癌的发病率以每年3%的速度增长[2],2008年的统计资料显示全球男性肾癌发病率的排名位居常见恶性肿瘤的第11位,女性位居第15位;发达国家肾癌的发病率最高,男性排名第6位、女性排名第11位;我国男性肾癌的发病率排名第12位,女性排名第17位[3].2004年世界卫生组织(WHO)重新制定了泌尿系肿瘤病理学检查标准,将肾癌分为:透明细胞癌(clear cell renal cell carcinoma,CCRCC)、多房囊性细胞癌、乳头状细胞癌(papillary renal cell carcinoma,PRCC)、嫌色细胞癌(chromophobe renal cell carcinoma,CRCC)、Bellini集合管癌、Xp11易位性细胞癌、神经母细胞瘤相关性细胞癌、髓样癌、黏液性管状及梭形细胞癌、未分类细胞癌,共10种亚型[4].由于新的病理学分类可较好体现肾癌各亚型独自的生物学行为,越来越多的泌尿外科医生希望术前预判肾癌亚型,这将有助于患者的术前评估和手术方案的制订,以避免过度治疗、减少手术并发症.本文旨在简要阐述肾癌常见亚型的生物学特性和CT特征,以便为临床工作提供借鉴.
作者 杨培谦
出处 《中华临床医师杂志(电子版)》 CAS 2013年第3期6-7,共2页 Chinese Journal of Clinicians(Electronic Edition)
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参考文献10

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同被引文献100

  • 1田军,马建辉.肾癌生物治疗的临床进展[J].肿瘤研究与临床,2006,18(11):721-725. 被引量:3
  • 2韩希年,彭令荣,刘光华,王俭.300例肾细胞癌CT表现分析[J].中华放射学杂志,2007,41(5):510-513. 被引量:34
  • 3杨学成,杨晓坤,董胜国,孔令波.肾嗜酸细胞瘤的诊治(附12例报告)[J].临床泌尿外科杂志,2007,22(5):334-335. 被引量:9
  • 4韩希年,彭令荣,刘光华,等.少脂肪肾血管平滑肌脂肪瘤多层螺旋CT表现[J].中华泌尿外科杂志,2007,28(12):855.
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  • 8Argani P,Antonescu CR,Illei PB,et al.Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma:a distinctive tumor entity previously included among renal cell carcinomas of children and adolescents[J].Am J Pathol,2001,159(1):179-192.
  • 9Argani P,Lui MY,Couturier J,et al.A novel CLTC-TFE3 gene fusion in pediatric renal adenocarcinoma with t(X,17)(p11.2,q23)[J].Oncogene,2003,22(34):5374-5378.
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