外科治疗重症肌无力的临床分析

The clinical analysis of surgical treatment on myasthenia gravis

回顾性分析在我院接受外科胸腺切除术治疗的行52例重症肌无力(MG)患者的临床资料,对术后近期疗效及危象发生情况进行统计学分析。结果显示手术后症状缓解15例,改善26例,无变化8例,恶化3例,总有效率为78.8%。Osseman分型、术前病程长短、术前溴吡斯的明用量及是否合并胸腺瘤是术后肌无力危象发生的相关危险因素。外科治疗MG具有良好的疗效,围术期做好充分准备并控制相关危险因素可降低术后危象的发生。

The clinic data of 52 cases with MG who underwent thymectomy from May 2008 to May 2013 were ana-lyzed retrospectively. The early outcome and crisis onset were analyzed by statistical methods. After operation, the symptom of MG was complete recieved in 15 cases, improved in 26 cases, unchanged in 8 cases, deteriorated in 3 cases. The total effective rate was 78. 8%. Osserman stage, the symptom duration before operation, the pre-opera-tive dose of pyridostigmine and thymoma were prognostic factors for postoperative myasthenic crisis. Surgical treat-ment shows significant clinical benefits for patients with MG. Full preparation and prevention for the prognostic fac-tors may reduce the occurrence of postoperative myasthenic crisis.