冠心病患者红细胞膜抵抗素含量的变化及其临床意义

Changes and clinical significance of resistin content of erythrocyte membranes in patients with coronary heart disease

目的：观察冠心病患者血清抵抗素与红细胞膜抵抗素含量的变化。方法：序贯入选接受行冠状动脉造影检查的患者273例,根据造影结果及临床表现,分为冠心病组210例,对照组63例。采用酶联免疫分析（ELISA）的方法检测各组血清抵抗素和红细胞膜抵抗素。结果：①冠心病组红细胞膜抵抗素含量[209.12（127.17-376.27）pg/mg]显著性高于对照组[182.15（85.96-293.07）pg/mg,P=0.018];②冠心病组血清抵抗素的含量[146.36（61.81-328.47）pg/ml]与对照组[130.12（68.6-278.7）pg/ml]之间无显著性差异（P=0.801）;③多因素逐步Logistic回归分析提示红细胞膜抵抗素是冠心病的危险因素,红细胞膜抵抗素每增加1pg/mg,发生冠心病的风险增加0.3%。结论：血清抵抗素水平与冠心病无相关性,而红细胞膜抵抗素含量增高与冠心病有显著相关性。

Objective：To observe changes of serum resistin levels and resistin content of erythrocyte membrane（REM）levels in patients with coronary heart disease（CHD）.Method：According to the coronary angiography results and clinical manifestations,273patients were divided into CHD group（n=210）and control group（n=63）.ELISA was used to detect the levels of serum resistin and REM.Result：①Compared with control group（182.15,85.96-293.07pg/mg）,REM content in CHD group（209.12,127.17-376.27pg/mg）was significantly increased（P=0.018）;②The serum resistin content had no significant differences between CHD group（146.36,61.81-328.47pg/ml）and control group（130.12,68.6-278.7pg/ml,P=0.801）;③Multi-factors stepwise logistic regression analysis showed REM had significant correlation with CHD and could be considered as a high-risk factors in CHD.The risk of coronary artery disease would arise by 0.3% accompanied with 1pg/mg increase of REM.Conclusion：Serum resistin levels have no correlationship with CHD,but REM has a significant correlationship with CHD.