摘要
目的探讨骨桥蛋白(OPN)和环氧化酶2(COX-2)在声门上型喉癌中的表达及意义。方法免疫组化法检测48例声门上型喉癌(A组)和癌旁组织(B组)中OPN和COX-2的表达。结果 A组OPN和COX-2表达均高于B组(89.58%vs.20.83%和85.42%vs.16.67%)(P<0.05)。OPN的表达与肿瘤分期、分级以及淋巴结转移密切相关(P<0.05);COX-2的表达与肿瘤分期、分级密切相关(P<0.05)。OPN和COX-2在声门上型喉癌组织中的表达呈正相关(P<0.05)。结论 OPN和COX-2有可能成为声门上型喉癌诊断的标志物和潜在治疗靶点。
Objective To explore the expressions and clinical significance of osteopontin（OPN） and cyclooxygenase-2 （COX-2） in supraglottic laryngeal squamous cell carcinoma. Methods The expressions of OPN and COX-2 were detected with immunohistochemistry in 48 cases of supraglottic laryngeal carcinoma（group A） and tumor-adjacent tissues（group B）. Results The expression rates of OPN and COX-2 were higher in group A than those in group B（89. 58% vs. 20. 83% and 85.42% vs. 16. 67%）（P〈0. 05）. Expression level of OPN in group A was significantly correlated with tumor stage, grade and lymph node metastases（P〈0. 05）. Expression level of COX-2 was significantly correlated with tumor stage and grade （P〈0. 05）. OPN in group A was positively correlated with COX-2（P〈0. 05）. Conclusion OPN and COX-2 may be the markers and potential therapeutic targets of supraglottic laryngeal squamous cell carcinomas.
出处
《江苏医药》
CAS
北大核心
2014年第9期1045-1047,共3页
Jiangsu Medical Journal
关键词
骨桥蛋白
环氧化酶2
声门上型喉癌
Osteopontin
Cyclooxygenase-2
Supraglottic laryngeal squamous cell carcinoma
