冠状动脉支架植入术对急性冠脉综合征患者血浆syndecan-4蛋白水平的影响

Effect of coronary artery stent implantation on plasma syndecan-4protein in patients with acute coronary syndrome

目的探讨冠状动脉支架植入术对急性冠脉综合征患者血浆syndecan-4蛋白水平的影响。方法急性冠脉综合征患者280例(A组),接受冠状动脉支架植入术治疗;同时选取无心脏病史人群120例作为对照(B组)。采用酶联免疫吸附法检测A组患者治疗前、治疗后1、24h和3d以及B组患者的血浆syndecan-4蛋白水平。结果 A组患者治疗前和治疗后1、24h的血浆syndecan-4蛋白水平均高于B组[(524.4±256.3)mmol/L、(723.3±351.4)mmol/L和(543.5±271.5)mmol/L vs.(423.2±254.3)mmol/L](P<0.05)。A组行冠状动脉支架植入术治疗后1h,血浆syndecan-4蛋白水平高于术前(P<0.05);治疗后24h血浆syndecan-4蛋白水平下降至术前水平。A组治疗后3d时的血浆syndecan-4蛋白水平(439.6±261.2)mmol/L低于治疗前(P<0.05),并与B组相仿(P>0.05)。结论急性冠脉综合征患者血浆syndecan-4蛋白水平明显升高;植入冠状动脉支架后24h进一步增高,3d恢复正常。血浆syndecan-4蛋白可能参与了血管急性机械性损伤和早期的血管炎症反应。

Objective To investigate the effect of coronary artery stent implantation on plasma syndecan-4 protein in patients with acute coronary syndrome（ACS）. Methods A total of 280 ACS patients（group A） undergoing coronary artery stent implantation and 120 cases（group B） without a history of heart diseases as the controls were included in the study. Plasma levels of syndecan-4 protein were detected by ELISA before and at 1,24, and 72 hours after operation in group A. The results were compared to those in group 13. Results Plasma levels of syndecan-4 protein of group A before and at 1 and 24 hours after operation were significantly higher than those of group 13[（524. 4±256. 3） mmol/L, （723.3±351.4） mmol/L and （543. 5±271.5） mmol/L vs. （423. 2±254. 3） mmol/L] （P〈0. 05）. Plasma level of syndecan-4 protein in group A was higher at 1 h than that before（P〈0. 05）, which was similar to that before at 24 h（P〉0. 05） and lower than that before at 72 hours（P〈0. 05）. Plasma level of syndecan-4 protein in group A at 72 hours after operation（439.6±261.2） mmol/L was similar to that in group B （P〉0. 05）. Conclusion Plasma syndecan-4 protein is highly expressed in ACS patients, which is even more within 24 hours after coronary artery stents implantation and restores to the normal on the 3^rd day. The syndecan-4 protein may participate in the vascular acute mechanical damage and its early vascular inflammation response.