抑郁症患者外周血三酰甘油水平的meta分析

Meta analysis of level of peripheral triglyceride of patients with depression

目的采用meta分析方法比较抑郁症患者和健康对照者外周血三酰甘油的水平。方法检索截至2013年10月的PubMed、EMBASE、中国学术期刊全文数据库（CNKI）、万方数据库、重庆维普和中国生物医学文献服务系统（SinoMED）等医学文献数据库，查找涉及抑郁症患者三酰甘油水平的病例对照研究和横断面研究，使用RevMan5．0软件进行分析。结果共纳入21项国内外文献，包含抑郁症患者1767例，健康对照者1950例。Meta分析结果显示抑郁症患者的三酰甘油水平显著高于对照组，为15．95（95％CI：8．87～20．03）mg／dL（1dL=100mL）（P〈0．00001）。亚组分析提示抗抑郁药物、年龄和体质量指数对三酰甘油水平有一定影响。结论抑郁症患者外周血三酰甘油水平显著升高，可能是代谢综合征的风险因子。

Objective To compare the level of peripheral triglyceride between patients with major depressive disorder （MDD） and healthy control （HC） subjects by the meta analysis. Methods Case-control studies or cross-sectional studies relevant to patients with depression were retrieved from the PubMed, EMBASE, China National Knowledge Internet, Wanfang Data, VIP, and SinoMED. The deadline of retrieval time was October, 2013. The analysis was conducted by the Review Manager 5.0. Results Twenty-one papers from home and abroad were selected, which included 1 767 patients with depression and 1 950 healthy control subjects. The results of meta analysis indicated that triglyceride levels of patients with depression were 15.95 （95% confidence interval： 8.87 -20.03） rag/dL （1 dL =100 mL）, which were significantly higher than those of healthy control subjects （P〈0. 000 01）. The subgroup analysis showed that antidepressants, age, and body mass index had certain effects on the triglyceride level. Conclusion The level of peripheral triglyceride of patients with depression elevates signiftcantly and may be the risk factor of metabolic syndrome.