氯吡格雷联合阿司匹林治疗不稳定型心绞痛的疗效观察

Clinical study on the treatment of unstable angina with clopidogrel and aspirin

目的:观察氯吡格雷联合阿司匹林治疗不稳定型心绞痛的临床效果。方法:选择2006年1月至2012年3月郏县人民医院心内科诊治的400例不稳定型心绞痛患者为研究对象。对照组(200例)给予阿司匹林,实验组(200例)给予氯吡格雷和阿司匹林,观察两组治疗6个月的效果及心血管事件的发生率。结果:治疗6个月后,实验组心绞痛较对照组明显缓解,心血管事件发生率显著降低,两组差异有统计学(P<0.05)。结论:氯吡格雷联合阿司匹林治疗不稳定型心绞痛可显著提高临床疗效,降低心血管事件的发生率。

Objective： To observe the effects of treatment and incidence of adverse cardiac events of unstable angina with clopidogrel and aspirin during 6 months. Methods ： 400 patients diagnosed as unstable angina in The First Pepeole Hospital of Jiaxian from January 2006 to March 2012 were selected as the research object. These patients were randomly divided into observation group（ treated with clopidogrel and aspirin） and control group （treated with aspirin）. The clinical outcome and the incidence of cardiac events of two groups were compared after 6 months. Results： Compared with control group, the clinical outcome of observation group was significantly better and the incidence of cardiac was lower. Conclusion ： The combined use of clopidogrel and aspirin for unstable angina patients could significantly improve clinical outcome and prevent adverse cardiac events.