经鼻蝶垂体瘤切除术后脑脊液鼻漏的影响因素分析

Risk factors in cerebrospinal fluid rhinorrhea following transnasosphenoidal resection of pituitary adenoma

目的探讨经鼻蝶入路垂体腺瘤切除术后发生脑脊液鼻漏的影响因素。方法回顾性分析129例垂体瘤患者经鼻蝶入路垂体瘤切除术的临床资料,判断术后发生脑脊液鼻漏的相关因素。结果术后发生脑脊液鼻漏9例。统计学分析显示,再次手术、术中脑脊液鼻漏及术者经验与术后脑脊液鼻漏的发生呈正相关(P<0.05)。结论再次手术、术中脑脊液鼻漏和术者经验可能使发生术后脑脊液鼻漏的风险增加。

Objective To explore the influential factors in postoperative cerebrospinal fluid rhinorrhea following transnasosphenoidal resection of pituitary adenoma. Methods Clinical data of 129 cases with pituitary adenomas resected via transnasosphenoidal approach was analyzed retrospectively. Results Postoperative cerebrospinal fluid rhinorrhea occurred in 9 cases. The number of operation, intra-operative cerebrospinal fluid rhinorrhea and experience of surgeon were associated with the occurrence of postoperative cerebrospinal fluid rhinorrhea （ P 〈 0.05 ） . Conclusion The number of operation, intra-operative cerebrospinal fluid rhinorrhea and experience of surgeon arc risk factors in postoperative cerebrospinal fluid rhinorrhea in transnasosphenoidal resection of pituitary adenoma.